Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs comparison to baclofen and other GABAB receptor-selective agonists.docVIP

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2017-05-15 发布于上海
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Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs comparison to baclofen and other GABAB receptor-selective agonists.doc

Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs comparison to baclofen and other GABAB receptor-selective agonists

Canningetal.Cough2012,8:7 /content/8/1/7 Cough RESEARCH OpenAccess Antitussiveeffectsoftheperipherallyrestricted GABABreceptoragonistlesogaberaninguinea pigs:comparisontobaclofenandotherGABAB receptor-selectiveagonists BrendanJCanning1*,NanakoMori1andAndersLehmann2 Abstract Background:Gastroesophagealrefluxdisease(GERD)isacommoncauseofchroniccough.Bothacidandnonacid refluxisthoughttoplayaroleintheinitiationofcoughingandcoughhypersensitivity.TheGABABreceptoragonist lesogaberanwasdevelopedasaperipherallyrestrictedanti-refluxtherapythatreducesthefrequencyoftransient loweresophagealsphincterrelaxa

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Antitussive effects of the peripherally restricted GABAB receptor agonist lesogaberan in guinea pigs comparison to baclofen and other GABAB receptor-selective agonists.docVIP