Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction a cross-sectional study.docVIP
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Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction a cross-sectional study
Cough
BioMedCentral
Research
Open Access
Features of cough variant asthma and classic asthma during
methacholine-induced brochoconstriction: a cross-sectional study
Hisako Matsumoto*1, Akio Niimi1, Masaya Takemura1,2, Tetsuya Ueda1,2,
Masafumi Yamaguchi1, Hirofumi Matsuoka1, Makiko Jinnai1, Kazuo Chin3
and Michiaki Mishima1
Address: 1Department of Respiratory Medicine, Kyoto University, Kyoto, Japan, 2Department of Respiratory Medicine, Kitano Hospital, Osaka,
Japan and 3Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Kyoto, Japan
Email: Hisako Matsumoto* - hmatsumo@kuhp.kyoto-u.ac.jp; Akio Niimi - niimi@kuhp.kyoto-u.ac.jp;
Masaya Takemura - masaya.takemura@charite.de; Tetsuya Ueda - t-ueda@nakatsu.saiseikai.or.jp; Masafumi Yamaguchi - myama@kuhp.kyoto-
u.ac.jp; Hirofumi Matsuoka - hiromtok@kuhp.kyoto-u.ac.jp; Makiko Jinnai - majin43@kuhp.kyoto-u.ac.jp; Kazuo Chin - chink@kuhp.kyoto-
u.ac.jp; Michiaki Mishima - mishima@kuhp.kyoto-u.ac.jp
* Corresponding author
Published: 9 March 2009
Received: 30 October 2008
Accepted: 9 March 2009
Cough 2009, 5:3
doi:10.1186/1745-9974-5-3
This article is available from: /content/5/1/3
? 2009 Matsumoto et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Little is known regarding mechanistic and phenotypic differences between cough
variant asthma (CVA), presenting with a chronic cough as the sole symptom that responds to
bronchodilators, and classic asthma with wheezing during methacholine inhalation. Here we
reported airway sensitivity, airway reactivity, and as the main concern, the appearance of cough and
wheezes during methacholine inhalation in patients with CVA or classic asthma.
Methods: We cross-sectionall
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