Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction a cross-sectional study.docVIP

Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction a cross-sectional study.doc

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Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction a cross-sectional study

Cough BioMedCentral Research Open Access Features of cough variant asthma and classic asthma during methacholine-induced brochoconstriction: a cross-sectional study Hisako Matsumoto*1, Akio Niimi1, Masaya Takemura1,2, Tetsuya Ueda1,2, Masafumi Yamaguchi1, Hirofumi Matsuoka1, Makiko Jinnai1, Kazuo Chin3 and Michiaki Mishima1 Address: 1Department of Respiratory Medicine, Kyoto University, Kyoto, Japan, 2Department of Respiratory Medicine, Kitano Hospital, Osaka, Japan and 3Department of Respiratory Care and Sleep Control Medicine, Kyoto University, Kyoto, Japan Email: Hisako Matsumoto* - hmatsumo@kuhp.kyoto-u.ac.jp; Akio Niimi - niimi@kuhp.kyoto-u.ac.jp; Masaya Takemura - masaya.takemura@charite.de; Tetsuya Ueda - t-ueda@nakatsu.saiseikai.or.jp; Masafumi Yamaguchi - myama@kuhp.kyoto- u.ac.jp; Hirofumi Matsuoka - hiromtok@kuhp.kyoto-u.ac.jp; Makiko Jinnai - majin43@kuhp.kyoto-u.ac.jp; Kazuo Chin - chink@kuhp.kyoto- u.ac.jp; Michiaki Mishima - mishima@kuhp.kyoto-u.ac.jp * Corresponding author Published: 9 March 2009 Received: 30 October 2008 Accepted: 9 March 2009 Cough 2009, 5:3 doi:10.1186/1745-9974-5-3 This article is available from: /content/5/1/3 ? 2009 Matsumoto et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Little is known regarding mechanistic and phenotypic differences between cough variant asthma (CVA), presenting with a chronic cough as the sole symptom that responds to bronchodilators, and classic asthma with wheezing during methacholine inhalation. Here we reported airway sensitivity, airway reactivity, and as the main concern, the appearance of cough and wheezes during methacholine inhalation in patients with CVA or classic asthma. Methods: We cross-sectionall

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