异种移植的研究进展_姚丹华.pdf

2013 12 20 12 Chin J Bases Clin General Surg Vol 20 No 12 Dec 2013 • 1437 • * * * R617A * * * Research Progress of XenotransplantationYAO Dan-hua LI You-sheng LI Jie-shou . Department of General * SurgeryJinling Hospital Medical School of Nanjing University Nanjing 210002 Jiangsu Province China Corresponding Author LI You-sheng E-mail liys@medmail. com. cn Abstract Objective To summarize the research progress of xenotransplantation. Methods Domestic and international publications about xenotransplantation were summarized and reviewed. ResultsHyperacute xenograft rejection was a huge problem for xenotransplantationbut it could be alleviated if the organs or tissues of donor were genetically modifi ed. So far the graft survival time differed greatly due to characteristics of different organ. Conclusions By reviewing the studies of relevant papers about xenotransplantationa comprehensive understanding of research background and a suitable research direction of xenotransplantation can be supplied. The graft organs or tissues from genetically modifi ed donors are expected to avoid or alleviate hyperacute xenograft rejection. Key wordsXenotransplantation Hyperacute xenograft rejection Transgenic Gene knock-out UNOS 1