创面愈合中基因治疗的进展-中国病理生理杂志.PDF

# 1296 # Chinese Journal of Pathophysiolo y 2002, 18( 10) : 1296- 1299 [ ] 1000- 4718( 2002) 10- 1296- 04 * 程 飚, 付小兵, 盛志勇 ( 304 , 100037) Development of gene therapy in wound healing CHENG Biao, FU Xiao- bin , SHENG Zhi- yon ( Dep artment of Trauma and Rep air , 304 th H osp ital , Beij ing 100037, China) A Review The basic concept of ene therapy is to introduce a therapeutic ene into a cell, whose ex pression can improve to healin of wound. To achieve this oal, the suitable therapeutic ene has been selected and delivered into the reparative cell, which is becomin a focal point works about ene therapy inwound heal in . There have been several different therapeutic enes and ene transfer strate ies that have been used in models of wound healin . This article discusses several methods that have been used to deliver enes encodin rowth factor proteins, stem cells into wounds and the advanta es/ disadvanta es of each approach. We hope a safe vectors system to deliver the effectual trans ene in wound healin . [ ] ; ; ; [ KEY WORDS] Gene therapy; Wound healin ; Stem cells; Growth substances [ ] R64 [ ] A [ 2, 3] , , , 1. 1 生长因子的基因治疗 [ 1] , 80 , Mor an , , [ 4] , ( - , , - ) , , [5- 9] ( transformin rowth factor- , TGF- ! ∀; ) ( epidermal rowth factor, EGF) ; ( insulin- like rowth factor, IGF) , , ( TGF- ) (basic fibroblast rowth factor, bFGF) ( vascular endothelial rowth factor, VEGF) , 1 , , , ( extracellular ma / ( - 610 ) trix, ECM) , , , ,