味觉嗜好学习、睡眠剥夺对老龄大鼠脑脊液氨基酸和代谢产物的影响.pdfVIP

墨鑫笠睦童喳妊堂墨，睡隧型变塑耋签太鼠照登邃氢基醒厘岱迸芒堑笪丝煎．筮!!翅 ·Z443· 味觉嗜好学习、睡眠剥夺对老龄大鼠脑脊液氨基酸及代谢产物的影响 马 隽1 刘丽萍 李 雷赵丽瑞1 蒋 晔’ 赵毅刚 宋磊刚 (河北体育学院，河北 石家庄050041) (摘要】 觉嗜好学习模型、36h睡眠剥夺模型，用HPLC法测定上述指标的变化并进行统计分析。结果味觉嗜好学习组脑脊液TRP显著低于对照组(P 剥夺操作升高了味觉嗜好学习组TIuP、5一HTP浓度。结论味觉嗜好学习、睡眠剥夺影响大鼠脑内某些氨基酸及代谢物的水平；味觉嗜好学习能改 善睡眠剥夺对机体的不良作用；睡眠剥夺损伤了味觉嗜好学习的记忆。 [关键词]味觉嗜好学习；睡眠剥夺；氨基酸；认知；记忆 [中图分类号】 R338．64[文献标识码]A [文章编号】 1005-9202(2010)17-2443-04 oftaste Influence and onanlillOacidsandmetabolic inCSFofrats preferencelearningsleepdeprivation products MA a／． Jun，LIU Lei，et Li·Ping，LI Hebei Education Physical 050041，Hebei，China College，Shijiazhuang To theinfluenceoftaste theconcentra． 【Abstract】Objectiveinvestigate preferencelearning(cTP)andsleepdeprivation(SD)on tionof BCAAinCSFof to the and ofthoseindicators．MethodsAfter TRP，5．HTP，GABA，and rats。andanalyzechangesrelationships CTPand36hSD models．thoseindicatorsweredeterminedHPLCmethod．ResultsTheconcentrationofTRPinCTP establishing by group Waft lowerthanthatincontrol inSD indicators’concentrationswere thanthose significantly group(P0．05)．All group remarkablyhisher inother or effectsofSDontheindicatorsWritE,reversed treatmentofSD P0．05)．The C1’P．The after groups(P0．0l bypre．establishing CTPincreasedtheconcentrationsofTRPand5．H7IPinCTP Theconcentrationsof acidsand group．Conclusions someamino metatmlic and areinfluencedCTPSD．TheadverseeffectsofSDon