血浆同型半胱氨酸与胱抑素C在急性脑梗死患者中含量变化探析.docVIP

血浆同型半胱氨酸及胱抑素C在急性脑梗死患者中含量变化的分析 　　[摘要]目的 通过对急性脑梗死患者血浆中同型半胱氨酸、胱抑素C含量的测定，探讨两者在急性脑梗死患者血浆中含量的变化。方法 选取2014年5月～2015年12月在瓦房店市中心医院神经内科住院治疗的60例脑梗死患者为研究对象（脑梗死组），选取我院体检中心40岁以上无脑血管病史30例健康人为对照组，比较脑梗死组与对照组血浆同型半胱氨酸与胱抑素C水平，脑梗死组患者各型之间以及与对照组血浆同型半胱氨酸、胱抑素C之间的比较，同时分析脑梗死组患者血浆同型半胱氨酸与胱抑素C的相关性。结果 脑梗死组与对照组血浆中同型半胱氨酸、胱抑素C水平比较，差异有统计学意义（P0.05）；血浆同型半胱氨酸与胱抑素C水平呈正相关。结论 血浆同型半胱氨酸和胱抑素C与急性脑梗死的发病密切相关 [关键词]脑梗死；同型半胱氨酸；胱抑素C [中图分类号] R743.3 [文献标识码] A [文章编号] 1674-4721（2016）08（a）-0049-03 [Abstract]Objective To test content of plasma homocysteine and cystatin C in patients with acute cerebral infarction and explore changes both in patients with acute cerebral infarction.Methods From May 2014 to December 2015，60 patients with cerebral infarction hospitalized in department of neurology of Wafangdian central hospital were selected as research objects （cerebral infarction group），30 healthy people over 40 years old without a history of cerebrovascular disease were selected as control group in our hospital medical center.Plasma homocysteine and cystatin C levels were compared between cerebral infarction group and control group，plasma homocysteine and cystatin C were compared between various types in cerebral infarction group and control group，the correlation between plasma homocysteine and cystatin C in cerebral infarction group was analyzed.Results The difference of plasma homocysteine and cystatin C levels was statistically significant （P0.05）；plasma homocysteine was positively correlated with cystatin C levels.Conclusion Plasma homocysteine and cystatin C is closely related with acute cerebral infarction attack. [Key words]Cerebral infarction；Homocysteine；Cystatin C 急性脑梗死是脑血管病中发病率较高的疾病之一，由于该病具有较高发病率、致残率的特点，故对影响疾病本身相关的因素进行认识与早期预防十分重要。目前脑血管病的一、二级预防包括对高血压、糖尿病、高脂血症等危险因素的干预与控制，同时还包括戒酒、戒烟、对动脉血管狭窄者的药物干预治疗等。然而大量的临床研究发现，很多动脉粥样硬化性脑梗死患者发病既无高血压病、糖尿病、高脂血症等脑血管病常见的危险因素，也无吸烟、饮酒等不良嗜好，人们研究发现这部分患者与血浆中同型半胱氨酸、胱抑素C的水平密切相关 1资料与方法 1.1一般资料 选取2014年5月～2015年12月在瓦房店市中心医院神经内科住院治疗的60例脑梗死患者为研究对象（脑梗死组），其中男34例，女26例；年龄40～80岁，平均（