高龄急性冠脉综合征患者介入及药物治疗并发严重出血高危因素的研究.pdfVIP

问北医药2011 年7 月第33 卷第 14 期 Hebei Medical Joumal ,2011 ,VoI 33 Jul No. 14 2097 doi: 10. 3969/J. issn.l002 响7386.2011.14.006 ·论辛苦· 高龄急性冠脉综合征患者介入及药物治疗并发 严重出血高危因素的研究 孙琪石宇点张健崔俊玉 [摘要] 目的探讨高龄( ~75 岁)怠性冠脉综合征(ACS) 患者介入及药物治疗并发严重出血发生 率及其高底因素。方法 高龄ACS 患者 162 例，根据治疗方法分为经皮冠状动脉介入水(PCI)纽 121 例及 药物治疗组41 例，比较2 纽闷院内严i:出Ja.发生4且，采用Logistic 回归分析严重l!lJa.的独立危险因素。 结果 总体出血发生率为 4. 3% (7/162) ,PCI 组与药物治疗组出血发生牟分别为 4.8% (2/41) 与 4.1% (5/12 1) ， 2 组比较差异元统计学意义(P0.05) 。年蛤80 岁、氯咣格雷、替罗非就负荷治疗可增加严爱 出血发生风险。结论 同药物治疗相比，PCI 治疗末增加高龄ACS 患者出血并发症。年龄 80 岁、氯坑格 雷、替罗非班负待治疗增加严爱出血发生率。 {关键词] 高龄;急性冠脉综合征;经皮冠状动脉介入术;出血 {中团分提号] R 54 1. 4 [文献标识码] A [文章编号] 1ω2 -7386(2011)14 -2097 … 03 Study on the high risk factors of hernorrhage cornplication in elderly patients with acute coronary syndrorne undergoing percuωn佣us coro刷即interven创。制drn时ication SUN Qí ,SHI Yujie ,ZHANG Jian , et al. CardiopulT1Wnary J;4ωcular Center ,General Hospítal 0/Beijing Command ,PU ,Be以nglω7∞， China [Abstract] Objective To investigate the incidence and high risk factors of hemorrhage complication in elderly patients ( ~75 yr) with acute coron町 syndrome (ACS) undergoing percutaneous coron町 intervention (PCI) and medication. Methods 162 oId patíents with ACS were dívided into two groups ,the 121 patients in PCI group were treated by PCI , however , the other 41 patients in medication group were treated by routine drug. The incídences of severe hemorrhage in hospítal were compared between the two 伊川ps ， and the independent risk factors of severe hemoπhage were analyzed by Logistic regression analysis for both groups. Results The total incidence of hemorrhage wω4.3% (7/162) ,which was 4.8% (2/41) 削d 4.1% (5/121) in PCI group and in medication group ,respectively ,there wa晶 no si阴ificant differ.暗nce between the two 锣Oups( P 0‘ 05 ). However the incidence o