好 树突状细胞及调节性T细胞相互作用研究进展_黄立锋.pdfVIP

610 Ch inese Journal of Pathophysiology 2008, 24( 3): 610- 616 [ ] 1000- 4718( 2008) 03- 0610- 07 * T 黄立锋, 姚咏明 , 盛志勇 (, 100037) Recent advances in the correlations between dendritic cells and regulatory T cells HUANG L i- feng, YAO Yong- m ing, SHENG Zh i- yong (B as ic R esearch D ep artm ent of B urns Institute, F irstH osp italAff iliated to PLA G eneralH osp ital, Be ij ing 100037, Ch ina E - ma il: c ff @ s ina com ) A Review Dendritic cells ( DCs), representing a heterogenous popu lation of professional antigen- presen ting cells, are the in itiators and m odulators of the mi m une responses. Stud ies ind icate that regulatory T cells con tribute to mi mune nu llipotency and mi m une suppression via cell- cell contact or cytok ine secretion. These two kinds of cells m ay be valuable tools form odulating mi m un ity in the setting of auto- mi mun ity, cancer, chron ic viral infections and graft rejec tion, etc. H ere w e d iscuss the current know ledge on the functions of regu latoryT cells and dend itic cells- based mi muno regulation and the applications. [ ] ; T; [ KEY WORDS] Dendritic cells; Regu latory T cells; Imm unoregulation [ ] R363 [ ] A ( dendritic cells, DCs) 1 DCs , . DCs的概念 DCs 1 ( antigen presenting cells, APCs), , DCs, , DCs . 2 DCs的分类 DCs T ( reg , u latory T cells, Tr)Tr DCs DCs , DCs DCs DCs APCsT , DCs DCs, [ 1] DCsTr (MHC) - III , 2 , ; MHC- III, , , DCs Tr DCs DCs( DCs1 DCs2) . 3 DCs的生物