BSGI与PEM差异.docVIP

BSGI与PEM差异 BSGI——乳腺专用伽玛成像技术 PEM——Positron Emission Mammography正电子发射乳腺成像 BSGI和PEM的临床表现非常相似的敏感性和特异性 给药量 有效剂量当量 钼靶成像 4个体位 n/a 0.7 mSv BSGI Sestamibi 10mCi 3.35 mSv PEM F-18 FDG 10 mCi 11.1 mSv 成像条件 下表所示为BSGI与PEM检测的特性， 辐射能量/光子 半衰期 禁食时间 注射后等待时间 建议预检测项目 F-18 （FDG） 511Kev 110分钟 4-6小时 60-90分钟 血糖测试 Tc-99 （Sestamibi） 140Kev 360分钟 无需 5分钟 无需 Sestamibi的半衰期约为FDG的3倍，由于FDG的短半衰期，会使PEM的临床诊断计划安排比较困难，例如患者比注射FDG的预约时间晚到1个小时，药剂将会损失32%的有效活度，而Sestamibi仅为9%。 PEM检查对患者要求比较多，需要在检查前禁食4-6小时，同时建议进行血糖测试，而BSGI没有这些要求。 FDG注射后需要等待60-90分钟才能进行成像，而MIBI只需要5分钟 3. 敏感性比较 下表为BSGI与PEM针对不同乳腺癌的敏感性的比较。 BSGI PEM Overall 96% 90% DCIS 94% 91% ILC 93% 75% Sub-centimeter 89% 63% Mammography Dosimetry American College of Radiology, Sestamibidosimetry for BSGI International Commission on Radiologic Protection. Radiation Dose to Patients from Radiopharmaceuticals. New York, NY: Permamon Press; 1988. ICRP Publication 53. Cardiolite Drug Data Sheet. Bristol Myers Squibb. May 2003. FDG Dosimetry for PEM Dosimetry - F-18-Fluorodeoxyglucose, NUREG/CR-6345, page 9, September 18, 1992. J.E. Kalinyak, MD, PhD. Comparison of Radiopharmaceuticals Used in Positron Emission Mammography (PEM) and Breast Specific Gamma Imaging (BSGI). White paper. Naviscan PET Systems, Inc., March 2007. BSGI - Brem RF. Floerke AC. Rapelyea JA. Teal C. Kelly T. Mathur V. Breast-specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology. 247(3):651-7, 2008 June. Brem R, et al. Breast Specific Gamma Imaging in Women with One Suspicious or Cancerous Breast Lesion. Invasive Lobular Carcinoma: Detection with Mammography, Ultrasound, Magnetic Resonance Imaging, and Breast-specific Gamma Imaging (BSGI). 2008 Radiological Society of North America Annual Meeting. PEM - Berg WA, Weinberg IN, Narayanan D, Lobrano ME, Ross E, Amodei L, TafraL,Adler LP, Uddo J, Stein W 3rd,Levine EA. High-resolution fluorodeoxyglucose positron emission tomography with compression (positron emission mammography) is highl