广州市番禺区番禺大道一期工程施工T。。。.ppt

The Human Genome Project;Introduction;Introduction;Human Genome Project;What does the draft human genome sequence tell us? ;What does the draft human genome sequence tell us?;What does the draft human genome sequence tell us? ;What does the draft human genome sequence tell us? ;What does the draft human genome sequence tell us? ;What does the draft human genome sequence tell us?;What does the draft human genome sequence tell us?;How does the human genome stack up?;? Gene number, exact locations, and functions ? Gene regulation ? DNA sequence organization ? Chromosomal structure and organization ? Noncoding DNA types, amount, distribution, information content, and functions ? Coordination of gene expression, protein synthesis, and post-translational events ? Interaction of proteins in complex molecular machines ? Predicted vs experimentally determined gene function ? Evolutionary conservation among organisms ? Protein conservation (structure and function) ? Proteomes (total protein content and function) in organisms ? Correlation of SNPs (single-base DNA variations among individuals) with health and disease ? Disease-susceptibility prediction based on gene sequence variation ? Genes involved in complex traits and multigene diseases ? Complex systems biology including microbial consortia useful for environmental restoration ? Developmental genetics, genomics ;Anticipated Benefits of Genome Research;Risk Assessment ? evaluate the health risks faced by individuals who may be exposed to radiation (including low levels in industrial areas) and to cancer-causing chemicals and toxins Bioarchaeology, Anthropology, Evolution, and Human Migration ? study evolution through germline mutations in lineages? study migration of different population groups based on maternal inheritance? study mutations on the Y chromosome to trace lineage and migration of males? compare breakpoints in the evolution of mutations with ages of populations and historical events ;DNA Identificat