表观遗传学分子机制与其研究进展.pdfVIP

36 卷33 期 孙永健等 表观遗传学的分子机制及其研究进展 1445 1 X RNA, tive-specific Transcript) , , RNA X , , 17 kb RNA X , DNA DNA X , X [ 7] RNA , / 0r XRNA, RNA , , MSL , X , X / 0, X [ 12] 2.3.2 RNARNA( RNA) , , mRNA , 3. 2 , , , RNA , ( ) RNA(sh rt interfering RNA, siRNA) RNA(micr R- NA, miRNA) , RNA (RNA interference) ( gen mic imprinting) [ 8] , RNA (genetic imprinting) (parental imprinting) , RNA siRNA, , RNA , , (RISC) , mRNA( RNA) mRNA -2 Igf 2( 7 ) , siRNA , [ 13] mRNA , ; , , , , miRNA 22 nt 5c3c ( allelic repressi n) ( im- RNA 3 : 1 printing c ntr l regi ns, ICRs) , 3c, mR- ICR NA ( lin-4) , miR- , , ICR NA ; 2 , siR- ; , NA mRNA ( miR- RNA( n n-c ding RNAs) , 171) ; 3 2 miRNA( let-7) [ 9] X , [14] 2.4 ( Pri n, pr teinace us infecti us particle) , 3. 3 , DNA sc PrP , , (transgene silence) c PrP , , DNA , , 2 : 1 (tran- Hsp90 , scripti nal gene silence,TGS) , [ 10] , bar 3 hp h , TGS 3.1 X X 2 (p st- , X transcripti nal gene silence,PTGS) , , , 2 X ( ) , hp h , X ( d sage c mpensati n) [ 11]