他克莫司软膏联合窄谱中波紫外线对白癜风治疗作用探究.doc

他克莫司软膏联合窄谱中波紫外线对白癜风治疗作用探究 　　[摘要] 目的 研究并分析治疗白癜风患者时使用他克莫司软膏联合窄谱中波紫外线治疗的效果。方法 整群收集该院2014年6月―2016年3月收治的白癜风患者共96例，根据随机对照原则分为对照组（48例）和观察组（48例），对照组接受窄谱中波紫外线治疗，观察组则联合他克莫司软膏涂抹患处，将两组患者治疗后的总有效率、不同部位皮损治疗效果以及不良反应发生率进行观察和对比。结果 观察组治疗后的总有效率为95.83%，显著高于对照组的79.17%，χ2=6.095，P=0.014；患者面颈部、四肢躯干的治疗效果更佳；两组患者均未发生严重不良反应。结论 在白癜风患者的治疗过程中，他克莫司软膏联合窄谱中波紫外线治疗能够使患者获得更佳疗效，值得推广应用 [关键词] 白癜风；他克莫司软膏；窄谱中波紫外线；联合治疗；治疗效果 [中图分类号] R758 [文献标识码] A [文章编号] 1674-0742（2016）12（b）-0137-03 Tacrolimus Ointment Research Combined with Narrow Spectrum Ultraviolet Therapeutic Effect on Vitiligo KE Jian-jin Putian Skin Disease Prevention and Treatment Hospital Dermatology， Putian，Fujian Province， 351100 China [Abstract] Objective To study and analyze the treatment of vitiligo patients using Tacrolimus Ointment combined with NB-UVB treatment effect. Methods Group collected from June 2014 to March 2016 in our hospital were 96 cases of vitiligo patients， according to the principles of randomized into control group （48 cases） and observation group（48 cases）， the control group received NB-UVB treatment， the observation group is a joint Tacrolimus Ointment daub， two groups of patients after treatment， the total efficiency in observation and comparison. Results The total effective rate of the observation group was 95.83%， significantly higher than that of the control group of 79.17%， χ2=6.095， P=0.014； patients with face and neck， limbs and trunk of the treatment effect is better； two groups of patients had no serious adverse reactions. Conclusion In the treatment of vitiligo， Tacrolimus Ointment combined with NB-UVB treatment can make the patients get better curative effect， it is worthy of popularization and application. [Key words] Vitiligo； Tacrolimus Ointment； Narrow-band ultraviolet treatment； Combination therapy；Treatment effect 白癜?L是指后天性泛发性或局限性皮肤色素脱失病，主要由皮肤黑素细胞功能消失引发，常见于手腕、指背、颜面、前臂、颈项等处[1]。目前白癜风的发病机制尚未明确，因此在临床中缺乏特异性的治疗药物[2]。近年来，窄谱中波紫外线逐渐应用在了白癜风的临床治疗中，且不断有研究报道称治疗效果较为理想[3]。而他克莫司软膏属于免疫抑制剂，在白癜风的临床干预当中也得