1 资料与方法 - 中华医学会.docVIP

绝经后女性催乳素裂解 宋继洋* 王楠 方砚 曹云山 （*宁夏医科大学临床医学院，银川 750000 中国；甘肃省人民医院心内科，兰州 730000 中国） 【摘要】 目的：探讨绝经后女性催乳素裂解高血压心功能不全的发病机制和防治策略提供新的理论依据。方法：选取甘肃省人民医院心内科和体检科绝经女性例，对照组（例）、高血压组（例）和高血压合并心功能不全组（例）测定全长催乳素（23Kd PRL）、催乳素片段（16Kd PRL）、脂质过氧化物（LPO）、总抗氧化能力（TAS）及左室射血分数（LVEF）、N末端脑利钠肽前体NT-proBNP）、肌酐、尿酸、空腹血糖及BMI指数等指标，并进行统计分析。结果：①各组间在年龄、肌酐、尿酸空腹血糖及BMI指数等方面无显著性差异（P0.05）。②高血压组LPO显著高于对照组（P0.01），TAS显著低于对照组（P0.05）；高血压合并心功能不全组LPO显著高于对照组和高血压组（P0.05），TAS显著低于对照组和高血压组（P0.01）。③高血压合并心功能不全组23Kd PRL显著低于对照组（P0.01，图2-Ⅱ）、16Kd PRL显著高于对照组（P0.01，图2-Ⅲ）、16Kd PRL/23Kd PRL显著高于对照组（P0.01，图2-Ⅳ）。④经Pearson相关分析LPO与23Kd PRL之间呈负相关（r=-0.7 P0.01）16Kd PRL之间呈相关（r=0. P0.01）TAS与23Kd PRL之间呈正相关(r=0.P＜0.01)与16Kd PRL之间呈相关（r=0.777 P0.01）Kd PRL与之间呈相关（r=0. P0.01）NT-proBNP之间呈相关（r=0.832 P0.01）Kd PRL与之间呈负相关（r=-0. P0.01）NT-proBNP之间呈相关（r=0. P0.01）。结论：氧化应激（OS）很可能是触发催乳素裂解的 【关键词】催乳素；脂质过氧化物；总抗氧化能力；氧化应激；高血压；心功能不全 tudy on correlation between prolactin cleavage and hypertension,heart failure in postmenopausal women patients SONG Ji-yang * WANG Nan FANG Yan CAO Yun-shan (*Ningxia Medical University,Yinchuan 750000 China; Ganshu Provincial Hospital,Lanzhou 730000 China) 【Abstract】 Objective: To investigate the prolactin cleavage and hypertension, heart failure in postmenopausal women, provide a new pathogenesis and prevention strategies for them. Method: A total of 216 postmenopausal patients from Gansu Province Peoples Hospital were divided into essential hypertension group (80 cases) and heart failure group (76 cases) in, and another 60 cases postmenopausal women of physical examination center as a control group,then testing the prolactin (23Kd PRL), prolactin fragment (16Kd PRL), lipid peroxide (LPO), total antioxidant status (TAS) and left ventricular ejection fraction (LVEF), NT-proBNP、creatinine, uric acid, fasting blood glucose and BMI. Results: ①There was no significant difference in terms of age, creatinine, uric acid, fasting blood glucose and BMI between the groups (P 0.05). ②Blood serum levels of LPO i