混合尖峰发放模型 神经科学概要1.pptVIP

文章解读（Hybrid spiking models） ——several kinds of models simulation methods of simple model of spiking neurons 问题探究 ——重现图2中不同神经元的活动模式，并指出 相应活动模式的参数 统计各种模式下发放率与输入刺激的强度之 间的关系 输入均值为 符合泊松分布的随机电脉冲， 考察均值与发放率之间关系 重现图2中不同神经元的活动模式，并指出相应活动模式的参数 —— form “Simple model of spiking neurons” 混合尖峰发放模型  To understand how the brain works, we need to combine experimentalstudies of animal and human nervous systems with numerical simulation of large-scale brain models. ——E.M. Izhikevich 神经元是生物体中信息传递的基本单元。 The leaky integrate-and-fire model v:membrane potential C:memberane capacitance gleak:leaky ohmic conductance Eleak:leaky reverse potential I:input current It lacks an intrinsic spike-generation mechanism, and hence is just a ‘threshold’ model. The quadratic integrate-and-fire model v:membrane potential C:memberane capacitance I:input current K:a positive parameter Vrest:resting potentials Vthresh: instantaneous threshold potentials A hybrid spiking model—as it combines a smooth spike-generation mechanism with autocatalytic upstroke of the spike and a hard ‘after-spike’ reset. Simple model of spiking neurons U:a recovery variable a: the time scale of u b: the sensitivity of u c: the after-spike reset value of v d: the after-spike reset of u Simple model of spiking neurons U:a recovery variable a: the time scale of u b: the sensitivity of u c: the after-spike reset value of v d: the after-spike reset of u Other hybrid spiking models All after-spiking resetting are the same. U：a conductance E:the reverse potential of u Simple model of spiking neurons Simulation methods 1)How to detect Vpeak crossing? 2)Strong synaptic conductances cause numerical instability. How to avoid numerical instability? Simple model of spiking neurons Simulation methods Detecting Vpeak crossing: linear interpolation Avo