《临床麻醉学》肌松药的临床应用.ppt

Pancuronium * * ? Dosage (mg/kg) Clinical Duration (min) ED95 0.06-0.07 ? Intubation (at t = + 2–3 min) 0.08-0.12 60-120 Relaxation (N2O/O2) 0.05-0.06 30-60 Relaxation (Vapor) 0.03 30-60 Maintenance 0.01-0.015 30-40 stimulation of the sympathetic nervous system usually cause an increase in heart rate, blood pressure, and cardiac output Pancuronium is cleared largely by the kidney A small amount (10–20%) is deacetylated去乙酰化 at the 3-position in the liver * * Pipecuronium * * ? Dosage (mg/kg) Clinical Duration (min) ED95 0.04-0.05 ? Intubation (at t = + 2–3 min) 0.08-0.