多囊卵巢综合征患者临床促排卵转体外受精-胚胎移植分析.pdfVIP

天津医药2008年4月第36卷第4期 261 多囊卵巢综合征患者临床促排卵转体外受精一胚胎移植分析 徐凤琴 张云山 摘要 目的：探讨应用克罗米芬(cc)+人尿促性腺激素(HMG)+人绒毛膜促性腺激素(HCG)促排卵与行超促排 卵的多囊卵巢综合征(PCOS)患者体外受精一胚胎移植(IVFF—ET)结局的差异。方法：常规门诊促排卵因卵泡发育过 多转为ⅣF—ET患者12例 (A组)；应用促性腺激素释放激素激动剂 (GnRH—a)常规长方案或短方案IVF—ET的 PCOS患者17例(B组)，对2组的促性腺激素(Gn)用量、促排卵天数、获卵数以及临床妊娠率等指标进行比较。结 果：2组患者促排卵天数、受精率、胚胎移植数及临床妊娠率差异无统计学意义(P0．05)；A组患者Gn用量比B组 患者用量少，但差异无统计学意义(P0．05)；A组患者平均获卵数明显少于B组(P0．05)；A组患者胚胎种植率高 于B组，差异有统计学意义(P0．05 o结论：PCOS患者应用CC+HMG+HCG进行促排卵，如卵泡发育过多。可改为 IVF—ET，这是一种有效的挽救周期的治疗方法。 关键词 多囊卵巢综合征 不育，女(雌)性 卵巢过度刺激综合征 受精，体外 胚胎移植 Analysis of PC0S Patients in NormaI Ovarian Stimulation and IVF-ET XU Fengqin，ZHANG Yunshan ARTCenter，TianjinObstetrics andGynecologyCentralHospital，Tianjin300052，China Abstract Objective：To investigate and compare the outcomes of PCOS patients in IVF-ET with and without GnRH—a． Methods：The days of Gn using，dosage of Gn，No．of egg retrieval and clinical pregnancy rate were compared between the 12 clincal stimulation patients using CC+HMG+HCG protocol without GnRH-a(group A)and 17 IVF-ET patients using GnRH-a(group B)．Results：There was no difference ofdosage ofGn，duration ofGn，E2 level of HCG day，insemination rate，implatation rate and pregnancy rate between group A and B．Th ere was a significant difference in the No．of egg retrieval and between group A and group B(P0．05)．Conclusion：Ⅱthere is too much follicle growth in PCOS patients in clinical ovarian stimulation．converting to theⅣF—ET without down regulation is another way to achieve the expected results in PCOS patients． Key words pelycystic ovary syndrome infertili~，female ovarian hypemtimulation syndrome fertilization in vitro embryotransfer 多囊卵巢综合征(PCOS)是造成育龄妇女不孕 进行促排卵治疗，但因卵泡发育过多转为IVF—ET，而未进行