重组人红细胞生成素在妇科围手术期贫血治疗中的应用研究现状.pdf

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 8 :729-732 ( ) 729 重组人红细胞生成素在妇科围手术期贫血治疗中的 应用研究现状 1 2 1* 李娟 ，陈志谦 ，吴强 （1. 南京医科大学附属肿瘤医院江苏省肿瘤医院妇瘤科，江苏 南京 210009；2. 沈阳三生制药有限责任公司，辽宁 沈阳 110027） [ 摘要 ] 抗对于妇科围手术期患者，由于术前贫血、术中失血或术后炎症，可能导致贫血状况愈加严重，而旨在改善患者预后和减少异体输 血的妇科围手术期血液管理措施越来越被重视。重组人红细胞生成素能显著升高贫血患者血红蛋白水平并减少输血需求，其应用于围手术 期贫血的纠正，已成为临床研究的新热点。综述重组人红细胞生成素治疗妇科围手术期贫血的作用机制、国内外临床研究及安全性研究。 [ 关键词 ] 重组人红细胞生成素；临床应用；妇科围手术期；贫血 [ 中图分类号 ] R713；R973.3 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2014）10-0729-04 Present Status of Research on Application of Recombinant Human Erythropoietin in the Treatment of Perioperative Gynecological Anemia 1 2 1 LI Juan , CHEN Zhiqian , WU Qiang ( 1. Department of Gynecological Oncology, Jiangsu Cancer Hospital, Cancer Hospital Affiliated to Nanjing Medical University, Nanjing 210009, China; 2. Shenyang Sunshine Pharmaceutical CO.,LTD., Shenyang 110027, China) [Abstract] Because of the anemia in the preoperative period, the loss of blood in the intraoperative period, or the inflammation in the postoperative period, the anemia of perioperative gynecological patients may be more serious. The perioperative blood management has attracted more and more researcher attention. The purpose of the management is to improve the prognosis of patients and to reduce allogeneic blood transfusion. Recombinant human erythropoietin could increase Hb levels and reduce transfusion requirements in anemia patients. Its application in the correction of perioperative anem