in the adventure of the dying detective,（冒险的垂死的侦探,）.pdf

EDITORS CORNER Virulence 3:6, 471–473; October 1, 2012; G 2012 Landes Bioscience Intoxication vs. infection A decade of studying Burkholderia pseudomallei virulence in a simple infection model Shandra R. Day and Costi D. Sifri* Division of Infectious Diseases International Health; University of Virginia Health System; Charlottesville, VA USA “He was indeed a deplorable spectacle. In The causative agent of meliodosis is infection, leading to the hypothesis that the dim light of a foggy November day the Burkholderia pseudomallei, a Gram-nega- nematode death was due to a neurotoxin or sick room was a gloomy spot, but it was tive soil saphrophyte endemic to Southeast paralytic agent. However, no toxin was that gaunt, wasted face staring at me from Asia and northern Australia.3 Several identified.6 Additional work by Gan et al. the bed which sent a chill to my heart. His attributes of B. pseudomallei, including its demonstrated that a relatively short (12 h) eyes had the brightness of fever, there was low infectious dose, ease of laboratory period of exposure to B. pseudomallei was a hectic flush upon either cheek, and dark culture and ability to cause disease through sufficient to kill a substantial portion of the crusts clung to his lips; the thin hands multiple routes including inhalational nematode population but that live bacteria upon the coverlet twitched incessantly, his exposure, has led to its classified