冻干（Freeze drying）.docVIP

冻干（Freeze drying） The first chapter is research summary Section 1 definition of freeze drying system products Freeze drying system uses freeze drying technology to dry the material, so as to achieve the purpose of storing goods. The principle of freeze drying technology is to use the frozen solution to remove moisture at the low temperature and low pressure from the frozen state without direct sublimation. A complete freeze dry production line, including freeze drying machine, aseptic isolation device, automatic feeding and discharging system, washing and drying irrigation system, weighing and compounding filter system, lamp checking device, rubber stopper cleaning machine and capping machine. Freeze drying machine is the key component of freeze drying system, and freeze-drying of the product is realized in the freeze drying machine. Freeze drying machine according to the structure, by the freeze-drying box or drying box, or water vapor condenser condenser, chiller, vacuum pumps and valves, electrical control components and other parts; according to the system, which consists of four main parts of refrigeration system, vacuum system, heating system, and control system. The drying cabinet and the vacuum condenser of the freeze drying machine require on-line cleaning (CIP) and on-line sterilization (SIP) function. The isolator is mainly used in the freeze drying system to provide the aseptic environment needed for the delivery of the product. The isolating device completely isolates the operator, the external environment and the operating object, avoiding interference and pollution between the operator, the operating environment and the object of operation. The European Union GMP believes that the use of isolation technology can minimize the impact on the operator, and greatly reduce the risk of microbial contamination of products in the sterile production environment. Automatic feeding system is to achieve automatic control linkage and freeze-dried core areas of equi