渐近混合群体的混合连锁不平衡及其遗传连锁推断.pdfVIP

遗 传 学 报 Acta Genetica Sinica , January 2006, 33 (1) ：12–18 ISSN 0379-4172 The Admixture Linkage Disequilibrium and Genetic Linkage Inference on the Gradual Admixture Population GUO Wei①, FUNG Wing-Kam Department of Statistics and Actuarial Science, the University of Hong Kong, Hong Kong, China Abstract: Through the theoretical analysis of the admixture linkage disequilibrium (ALD) in the gradual admixture (GA) model, in which admixture occurs in every generation, the ALD is found to be proportional to the difference in marker allele frequencies, p - p , between two subpopulations. Based on this property, we can employ a strict monotonic function (Δ =Δ/ ( p -p ), where Δ 1 2 ker 1 2 denotes the linkage disequilibrium (LD) ) of the recombination fraction between the marker locus and the disease locus to infer the true genetic linkage. We construct a quasi likelihood ratio test (LRT) for the case-only data utilizing the information of unlinked markers in the human genome. The simulation results show that our tests can be used to fine map a disease locus. The effects of parameter values in the ALD mapping are also discussed. Key words: admixture linkage disequilibrium (ALD); linkage disequilibrium (LD); gradual admixture (GA) model ；hybrid isola- tion (HI) model; likelihood ratio test (LRT) When there has been a recent admixture between ture occurs only in the first generation, has been dis- two populations with different prevalence for a cer- cussed by a number of authors [1,7], and the GA model, tain disease and with markers having large allele fre- in which admixture occurs in every generation, has quency differences between two parental populations, been