Losec PUB文献Comparison of the effects of intravenous infusion of omeprazole and H2-receptor antagonists on intragastric pH in bleeding duodenal ulcer patients.pdfVIP

Chinese Journal of Digestive Diseases 2001; 2; 13-16 Comparison of the effects of intravenous infusion of omeprazole and H2-receptor antagonists on intragastric pH in bleeding duodenal ulcer patients ZHONG BIHUI, YUAN YUHONG, CHEN MINHU, LIN JINKUN HU PINJIN Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, China OBJECTIVE: To evaluate the effects of intravenous The famotidine group had mean and median infusion of omeprazole and H -receptor antagonists intragastric pH values above 4. In the other two 2 on 24-h intragastric pH levels in patients with groups, pH values were both below 4. The mean bleeding duodenal ulcers. percentages of time that intragastric pH levels were 4, 5 and 6 over the 24 h period in each of METHODS: Fifty patients with active bleeding the treatment groups were found to increase in the duodenal ulcers were randomly assigned to receive following order (smallest percentage to largest one of four treatment regimens: 40 mg omeprazole by percentage): omeprazole, famotidine, ranitidine and intravenous infusion every 12 h, 40 mg famotidine cimetidine. intravenously every 12 h, 50 mg ranitidine intra- venously every 6 h, 200 mg cimetidine intravenously CONCLUSIONS: The effect of intravenous use of every 6 h. Intragastric pH values were monitored in o