抑郁性失眠的药物治疗进展（Progress in drug treatment for depressive insomnia）.docVIP

抑郁性失眠的药物治疗进展（Progress in drug treatment for depressive insomnia） Depressive insomnia is associated to the somatic symptoms of depression, the main characteristics of REM sleep latency period shorten, early awakening, deep sleep, and reduced the volume of REM sleep, wake up is hard to fall asleep again, every night sleep time decreased significantly, the severity of insomnia, often with a direct relationship between the severity of depression, so for this kind of insomnia cant simply use sleeping pills or behavior therapy, more important is the treatment of depression at the same time. In this paper, we compared several antidepressants and discussed the drug treatment of depressive insomnia. 1 drug therapy Monoamine oxidase inhibitors (MAOI), is a kind of selective inhibition of monoamine oxidase activity in vivo drug, its mechanism is through the inhibition of monoamine oxidase activity, reduce in monoamine neural transmitter in the central nervous system degradation, relatively improve central single amine neurotransmitter levels, resulting in a antidepressant effect. Such drugs are applied to the early clinical type of antidepressant drugs, mainly have isopropyl hydrazine, phenelzine, such as medicine, but because of the adverse reaction is more, and the curative effect is better than succeeding tricyclic antidepressants, hence clinical less than now. In recent years to develop A new selective monoamine oxidase inhibitors, on behalf of the drugs for Mr Amine chloride, its pharmacological effects is selective inhibition of MAOA, and reversible inhibition, no cholinergic receptor blockade effect, retained the antidepressant effect, abandoned the traditional MAOI adverse reactions and TCA anticholinergic adverse reaction, its antidepressant effect work fast, adverse reaction is low, it is A kind of safe and effective antidepressant. Tricyclic antidepressants (TCA) : belongs to the first generation of monoamine reuptake inhibitors, not only can inhibit the 5 - HT and