抗SSB抗体检测在系统性红斑狼疮中临床意义.docVIP

抗SSB抗体检测在系统性红斑狼疮中临床意义【摘 要】目的探讨抗SSB抗体对系统性红斑狼疮(SLE)诊断的敏感性和特异性,并了解其与SLE临床表现的关系。方法 采用线型免疫印迹（LIA）法检测SLE患者与对照组血清抗SSB抗体,并记录SLE患者的主要临床表现,分析其与抗SSB抗体的关系。结果 74 例SLE 患者血清中25．7%抗SSB抗体阳性,30例对照组仅3．3%阳性，抗SSB抗体在SLE中检测的敏感性25．7%，排除类风湿关节炎（RA）和原发性干燥综合征（pSS）后抗SSB抗体在SLE中检测的特异性为96．7%。抗SSB抗体阳性组的SLE 患者颊部红斑、脱发、浆膜炎、继发性干燥综合征（sSS）、周围血象减低、IgG升高、抗SSA60抗体阳性、抗SSA52抗体阳性及两者均阳性的发生率显著高于抗SSB抗体阴性组 ( P＜0．05) 。结论 抗SSB抗体对SLE的诊断有重要意义，与颊部红斑、脱发、浆膜炎、sSS、周围血象减低、IgG升高、抗SSA60抗体阳性和或抗SSA52抗体阳性有一定相关性。 【关键词】 SSB抗体；红斑狼疮,系统性；线型免疫印迹 Significance of anti-SSB in systemic lupuserythematosusSANG Dao-qian. The Affiliated Hospital of Anhui Bengbu Medical College, Bengbu 233004， China 【Abstract】 Objective To investigate the diagnostic specificiy and sensitivity of anti-SSB on systemic lupus erythematosus (SLE)，and to analyze the relationship between anti-SSB and clinical manifestations of SLE．Methods The line immuno assy(LIA) was used to measure the anti-SSB in serum of 74 SLE patients,30 patients with other rheumatic diseases．Results Of the 74 SLE patients,25．7% were seropositive for anti-SSB．Only 3．3% of 30 control patients were seropositive；The sensitivity and specificity of anti-SSB in SLE were 25．7% and 96．7%，respectively when rheumatoid athritis (RA) andprimary Sj?gren′s syndrome(pSS) were excluded．The incidences of malar rash，hair thinning，serositis and second Sj?grgen′s syndrome(sSS) in anti-SSB positive SLE significantly higher than those of anti-SSB negative SLE (P＜0．05)．The incidences of leucopenia，neutropenia，IgG hyperinmmunoglublinemia，anti-SSA60 positive,anti-SSA52 positive and bothanti-SSA60 and anti- SSA52 positive in anti-SSB positive SLE also significantly higher than those of anti-SSB negative SLE(P＜0．05)．Conclusion Anti-SSB is one of the valuable marker in diagnosis of SLE；anti-SSB may have a close relationship with malar rash，hair thinning，serositis，leucopenia，neutropenia,IgG hyperinmmunoglublinemia，anti-SSA60 positive，anti-SSA52 positive． 【Key words】 Anti-SSB；Lupus erythematosus,Systemic；Line im