中西结合诊治早中期原发慢性肾脏病临床研究.docVIP

中西结合诊治早中期原发慢性肾脏病临床研究[摘要] 目的 观察中西医结合、个体化治疗早中期原发慢性肾脏病的临床疗效，延缓慢性肾衰竭的进程。方法 对43例早中期慢性肾脏病患者采用饮食营养、西药治疗（包括降压、调脂等）结合中医辨证论治。 结果 43例患者治疗后不仅能改善症状与证候，减少尿蛋白及尿红细胞，降低血肌酐，且治疗1年后，患者的GFR较治前有明显升高，差异有统计学意义。结论 中西医结合、个体化治疗早中期慢性肾脏病患者，不仅能延缓肾功能减退的速率，且能逆转部分患者的病情。 [关键词] 慢性肾小球肾炎；CKD2-3期；慢性肾脏病；中西医结合治疗 [中图分类号] R692 [文献标识码] B [文章编号] 1673-9701（2011）35-44-03 Clinical Analysis of Integrative Medicine in Diagnosis and Treatment of Early or Mid-term Primary Chronic Kidney Disease YIN Jiazhen Department of Nephrology，Guangxing Hospital Affiliated to Zhejiang Chinese Medical University，Hangzhou Hospital of TCM，Hangzhou 310007，China [Abstract] Objective To observe the individual therapy combined Traditional Chinese Medicine（TCM） and Western Medicine（WM） for the early and Med-primary chronic kidney disease， and the delaying process of chronic renal failure. Methods Apply the diet nutrition，western medicine（reducing blood pressure and adjusting lipid）combined with TCM treatment based on the dialectical theory of governance to 43 cases of the early and Med-primary chronic kidney disease patients. Results The patients were not only relieved of symptoms and signs，reduced urinary protein，red cells and Serum creatinine，but also raised GFR obviously after one year treatment. The difference was statistically significant. Conclusion The individualized treatment of combining TCM with WM not only can defer the rate of renal dysfunction，but also can reverse the disease in some early and Med-primary chronic kidney disease patients． [Key words] Chronic Glomerulonephritis；CKD2-3 period；Chronic Kidney Disease；Treatment combined TCM and WM 肾功能衰竭作为所有慢性肾脏病（chronic kidney disease，CKD）病变进展中不断严重化的结果，众多研究显示对慢性肾脏病进行早期干预治疗，对于患者的肾功能损害和衰竭以及对患者血管合并症带来缓解的作用，可以减少该病症的死亡率[1]。对早期干预治疗慢性肾脏病的研究具有一定的意义，也成为当今国内外肾脏病学界的研究重点和热点。同时，中西医结合诊治肾脏病在临床上有其一定优势。 1 资料与方法 1.1 一般资料 入选标准：年龄16～70岁，性别不限，符合慢性原发性肾小球疾病的临床诊断，CKD2～3期，经各项检查排除由乙型肝炎、糖尿病、系统性红斑狼疮等所致继发性肾损害者。随访时间1年以上，最终选取43例患者作为观察对象，其中男22例，女21例，男女之比为1.05∶1。年龄22～68岁，平均（43.44