丹参注射液联合大剂量糖皮质激素治疗肾病综合征临床观察.docVIP

丹参注射液联合大剂量糖皮质激素治疗肾病综合征临床观察[摘要] 目的：观察丹参注射液联合大剂量糖皮质激素治疗原发性肾病综合征的疗效及其安全性。方法：90例原发性肾病综合征患者分成3组, 常规激素组仅接受强的松治疗；大剂量激素组则使用大剂量激素冲击疗法；联合治疗组则以丹参注射液联合大剂量激素治疗。同时观察患者肾功能、血清白蛋白的变化及不良反应。结果：联合治疗组和大剂量激素组的肾功能参数、血清清蛋白均较常规激素组显著改善，而且疗效也较好。其中联合治疗组的血Cr和BUN显著好于大剂量激素组，且副作用也较大剂量组少。结论：丹参注射液联合大剂量激素可有效治疗原发性肾病综合征，而且副作用较少。 [关键词] 肾病综合征；丹参注射液；甲基强的松龙；强的松 [中图分类号] R692．9[文献标识码]B [文章编号]1673-7210（2008）03（b）-076-03 Clinic research of the treatment of refractory nephritic syndrome with Salviac Miltiorrhizae Injection and high-dose methylprednisolone LAI Wen-yan*, CHEN Guo-qing, LU Man, CHEN Kang, LI Guan-he （Nephrology Department of Hospital Workers Treated of the Western South China Sea oil Company, Zhanjiang524057, China） [Abstract] Objective: To research the effect and safety of Salviac Miltiorrhizae Injection and high-dose methylprednisolone in the treatment of nephritic syndrome.Methods:90 cases with nephritic syndrome were randomly divided into 3 groups: combined treatment group,high-dose methylprednisolone group and prednisone group．Patients in the combined treatment group were given Salviac Miltiorrhizae Injection and high-dose methylprednisolone. Ones in high-dose methylprednisolone group were just given high-dose methylprednisolone.Routine drug therapy was used as the prednisone group．The renal function parameters, Serum Albumin and the side effect of patients were observed.Results:The efficacy, renal function parameters and Serum Albumin ofthe combined treatment group and the high-dose methylprednisolonegroup were much better than that of the prednisone group．The blood Cr and BUN obviously decreased in the combined treatment group, and the side effect was less than the high-dose methylprednisolone group．Conclusion:Salviac Miltiorrhizae Injection and high-dose methylprednisolone are effective on primary nephritic syndrome. [Key words] Primary nephritic syndrome; Salviac Miltiorrhizae Injection; Methylprednisolone; Prednisone 目前对大剂量激素冲击治疗肾病综合征意见不一，我们观察到激素冲击疗法短期内产生相当高的血药浓度，