丹参酮ⅡA 对充血性心力衰竭患者心功能及血管内皮细胞分泌功能影响.docVIP

丹参酮ⅡA 对充血性心力衰竭患者心功能及血管内皮细胞分泌功能影响摘要：目的 研究丹参酮ⅡA 对充血性心力衰竭患者的心功能以及血管内皮细胞分泌功能的影响。方法 选择102例慢性心衰患者，根据美国纽约心脏病协会（NYHA）分级标准进行心功能分级，使用放射免疫法和双抗体夹心酶联免疫吸附法分别测定血管性假血友病因子（vWF）和6酮前列腺素F1α（6 keto PGF1α），同时用比色法测一氧化氮（NO），ELISA 法检测N末端脑钠素原（NT proBNP），超声心动图测左室射血分数（LVEF），并与健康对照组42 名进行比较。心衰患者随机分为常规组和丹参酮ⅡA组，治疗2周后复查各指标。结果 心衰心功能Ⅲ级、Ⅳ级组与对照组比较，血NO、NT proBNP及LVEF 差异有统计学意义（P＜0.05 或P＜0.01）； vWF 和6 keto PGF1α在对照组与心衰各心功能分级间差异有统计学意义（P＜0.05）。治疗2 周后，丹参酮ⅡA 组心功能明显改善，血浆vWF 及6 keto PGF1α含量升高（P＜0.05），且丹参酮ⅡA 组较常规组LVEF 明显增加，NT proBNP及血NO 明显降低（P＜0.05）。结论 血管内皮细胞功能、vWF 和6ketoPGF1α与心衰严重程度有关，丹参酮ⅡA 组可明显改善慢性心衰患者心功能，与血管内皮细胞功能改善有关。 关键词：丹参酮ⅡA；充血性心力衰竭；血管内皮细胞；血管性假血友病因子；6酮前列腺素F1α 中图分类号：R541.6 R289.5 文献标识码：B 文章编号2012 The Influence of Sodium Tanshione ⅡA on Cardiac Function and Secretive Function of Vascular Endothelial Cell in Congestive Heart Failure Li Chaoliang,Huang Wenyan,Shi Qiuling,et al // Nan’ao People’s Hospital of Shenzhen City (Shenzhen 518121) Abstract:Objective To observe the influence of sodium tanshioneⅡA on cardiac function and secretive function of vascular endothelial cell in congestive heart failure (CHF).Methods One hundred and two patients with CHF were studied.The level of von Willebrand factor (vWF) was detected by radioactive immunity method.The levels of plasma 6ketoprostaglandin F1α(6ketoPG F1α) and aminoterminal probrain natriuretic peptide (NTproBNP) was determined by ELISA.Nitric oxide (NO) was detected by enzymic method.Left ventricular ejection fraction (LVEF) was measured by ultrasonography.The results were compared with those of 42 healthy individuals.One hundred and two patients were randomized to receive conventional therapy and sodium tanshione ⅡA therapy and were followed up for 2 weeks.Results There was significant difference in plasma NO,NTproBNP and LVEF among healthy individuals and New York Heart Association (NYHA) class Ⅲ or class Ⅳ (P＜0.01).After treatment,plasma vWF and 6ketoPGF1α in sodium tanshione ⅡA group was positively and negatively related