乙酰唑胺对缺氧耐受小鼠血清T-chE及T-AOC影响.docVIP

乙酰唑胺对缺氧耐受小鼠血清T-chE及T-AOC影响.doc

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乙酰唑胺对缺氧耐受小鼠血清T-chE及T-AOC影响

乙酰唑胺对缺氧耐受小鼠血清T-chE及T-AOC影响【摘要】目的:研究乙酰唑胺对小鼠缺氧耐受的影响和机制。方法:小鼠随机分四组:生理盐水对照组、心得安对照组、乙酰唑胺高剂量组和乙酰唑胺低剂量组。高剂量组予以乙酰唑胺1 g/kg、低剂量组予以乙酰唑胺0.2 g/kg灌胃,阳性对照组给予心得安0.16 g/kg灌胃,正常对照组用20 g/kg生理盐水灌胃,各组小鼠均每天灌胃一次,连续5天并于末次给药1小时后测定小鼠在室温空调25℃条件下的常压缺氧耐受能力;同时在小鼠死亡时尽快断头取血,以3000 r/min,离心5分钟,按试剂盒说明书测定血清胆碱酯酶(T-ChE)活性和总抗氧化能力(T-AOC)。结果:乙酰唑胺低剂量组和高剂量组小鼠耗氧率均较生理盐水组显著降低(均P0.01),与心得安组比较差异有显著性(分别P0.01和P0.05);乙酰唑胺高剂量组T-ChE活性和T-AOC均明显比生理盐水组高(均P0.01),比心得安组显著增高(分别P0.01和P0.05)。结论:乙酰唑胺高、低剂量均能提高小鼠抗常压的缺氧耐受能力,与提高T-AOC和T-ChE活性有关。 【关键词】乙酰唑胺;缺氧耐受;耗氧率;胆碱酯酶;小鼠 文章编号:1009-5519(2007)11-1585-03 中图分类号:R33 文献标识码:A Effects of acetazolamide on the ability of anti-anoxia and the vitality of T-ChE and T-AOC in serum in mice LIANG Zhi-feng1, LIN Jun2,CHEN Chun-hui3,et al. (1.Department of Physiology;2.Department of Pharmacology;3.Class 2 of Grade 2003,Department of clinical medicine,Guangxi Medical University,Guangxi 530021,China) 【Abstract】Objective: To study the effects and mechanism of acetazolamide on the ability of anti-anoxia in mice.Methods:Mice were divided into four groups at random.Acetazolamidehigh dose group was intragastric administration with acetazolamide 0.1 g/kg/d but the low dose 0.02 g/kg/d, Propranolol group was intragastric administration with Propranolol 0.16 g/kg/d, and saline group was intragastric administration with saline 20 g/kg/d, all the mice were treatmed for 5 days. At last time, the mice were put in a jar to test the ability of anti-anoxia after intragastric administration for 1 hour,and the serum activity of T-ChE and T-AOC was measured respectively.Results:Both of acetazolamide high dose and low dose groups were improved the ability of ant-anoxia very significantly(both P0.01), and the T-ChE and T-AOC activities of the serum were improved significantly (all P0.01). Conclusion:The acetazolamide can improve the ability of anti-anoxia by improving the T-AOC and T-ChE activities. 【Key words】Acetazolamide;anti-anoxia ability;T-ChE;T-AOC;Propranololi hydrochloridum;Mouse 乙酰唑胺是一种碳

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