药物非隔室模型分析.pptVIP

NONCOMPARTMENTAL ANALYSIS;GENERAL PRINCIPLES OF STATISTICAL MOMENTS;Examples of Statistical Moment Usage;In statistics, the mean is a measure of a sample mean and is actually an estimate of the true population mean. In pharmacokinetics, we can calculate the moment of the theoretical probability density function (i.e., the solution of a differential equation describing the plasma concentration time data), or we can calculate moments from measured plasma concentration-time data. These curves are referred to as sample moments and are estimates of the true curves. ;Assume a theoretical relationship of C(t) as a function of time. The non-normalized moments, Sr , about the origin are calculated as:;Non-normalized moments Kinetic parameter;From: Rowland M, Tozer TN. Clinical Pharmacokinetics – Concepts and Applications, 3rd edition, Williams and Wilkins, 1995, p. 487.;Normalized moments Kinetic parameter;AREA DETERMINATION;B. Numerical Integration;B. Numerical Integration;B. Numerical Integration;隐搏窃晋徒贪浙彬潍望汉越决奢你起绕脸翠鸟斟脸妄遁东括孝控抽吾遭垄药物非隔室模型分析药物非隔室模型分析;B. Numerical Integration;B. Numerical Integration;B. Numerical Integration;檄扩拷烃坍态峻俐踪旭蜒矢锑侣扣饱螺腋骏裂嘲炔填乃涝凹捕泻炉句蚜签药物非隔室模型分析药物非隔室模型分析;Time (hr) C (mg/L) 0 2.55 1 2.00 3 1.13 5 0.70 7 0.43 10 0.20 18 0.025;散磁客塘酸哉食武搁炔淀筋辨捐臻易献短褒犬蔚朵仰氏莎稼通卷始捷代栗药物非隔室模型分析药物非隔室模型分析;CLEARANCE CONCEPTS;Rate In = QCa;Extraction Ratio: Ratio of the rate of xenobiotic elimination and the rate at which xenobiotic enters the organ.;Clearance: The volume of blood from which all of the drug would appear to be removed per unit time.;Relationship between CL Q;Total Clearance;Total Clearance;Additivity of clearance;Exception: sig. pulmonary elimination;100 mg drug administered to a volunteer resulted in 10 mg excreted in urine unchanged:;Application of Clearance Concepts;Application of Clearance Concepts;Mechanisms of altered elimination;STEADY-STATE VOLUM