Mast cells, angiogenesis, and tumour gro Mast cells, angiogenesis, and tumour gro 肥大细胞、血管生成和肿瘤.pdf

BBADIS-63198; No. of pages: 7; 4C: Biochimica et Biophysica Acta xxx (2010) xxx–xxx Contents lists available at ScienceDirect Biochimica et Biophysica Acta journal homepage: www.el /locate/bbadis Review ☆ Mast cells, angiogenesis, and tumour growth Domenico Ribatti a,⁎, Enrico Crivellato b a Department of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy b Department of Medical and Morphological Research, Anatomy Section, University of Udine Medical School, 34100 Udine, Italy a r t i c l e i n f o a b s t r a c t Article history: Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis. Since this early Received 25 June 2010 account, ample evidence has been provided highlighting participation of MCs to the inflammatory reaction Received in revised form 8 October 2010 that occurs in many clinical and experimental tumour settings. MCs are bone marrow-derived tissue-homing Accepted 24 November 2010 leukocytes that are endowed with a panoply of releasable mediators and surface receptors. These cells actively Available online xxxx take part to innate and acquired immune reactions as well as to a series of fundamental functions such as angiogenesis