Nordy微泡抗肿瘤血管治疗的超声造影及微血管密度分析.docVIP

Nordy微泡抗肿瘤血管治疗的超声造影及微血管密度分析 杨正春1，李锐2，黄泽君，陈朝晖 （1.重庆市妇幼保健院超声科，重庆 400013；2.第三军医大学西南医院超声科,重庆400038） [摘要] 目的 探讨超声造影对兔VX2肿瘤组织抗血管生成治疗疗效的评估价值。方法 40只VX2肿瘤模型兔随机分为实验组与对照组。实验组抗肿瘤血管生成治疗后与对照组同时进行超声造影，然后均进行微血管密度（MVD）测定，再进行相关分析。结果 （1）实验组与对照组肿瘤组织MVD有显著差异（P0.01）。 (2).超声造影最大回声强度比（IMAX）R73-36 [文章标志码] A The analysis of ultrasound contrast perfusion parameters and the microvessel density about the effect of Nordy-carrying Lipid Micro bubble with ultrasound destruction on anti-angiogenesis of tumors Yang Zhengchun1, Li rui2 , Huang Zejun, Chen Zhaohui 1 Department of Ultrasonography Chongqing health center for women and children ,Chong qing 400013,China; 2 Department of Ultrasonography , XINAN Hospital , the Three Military Medical University , Chong qing 400038,China Abstract: Objective：To observe the ultrasound contrast perfusion parameters about the effect of Nordy-carrying lipid microbubble with ultrasound destruction on anti-angiogenesis of Rabbit VX2 muscle implanted tumors. Methods：40 rabbits implanted VX2 muscle tumor were randomly divided into the control group and the experimental group. The parameters of blood perfusion were measured and analyzed by Contrast-enhanced ultrasound. And the MVD was detected by immunohistochemistry staining to observe tumor microvascular angiogenesis in each groups. Finally, correlation was analyzed with the parameters and MVD. Results: (1) The MVD detected in Experimental group and control group tumor were significantly different (P 0.01). (2) Maximum echo intensity ultrasound contrast ratio (IMAX) was positively correlated with MVD, but the rise time (RT) and peak time (TTP) was negatively correlated with MVD (r = 0.6794, -0.6154, -0.6977). (2) The experimental group was significantly lower than the control group in IMAX, RT and TTP was significantly higher(P 0.01). Conclusions： Nordy-carrying lipid microbubble with ultrasound destruction on anti-angiogenic therapy is effective, and the ultrasound contrast, which can indirectly