原发性肝癌介入治疗后并发肝性脑病的相关危险因素分析.docVIP

原发性肝癌介入治疗后并发肝性脑病的相关危险因素分析 [摘要] 目的 探讨原发性肝癌(PLC)介入治疗后并发肝性脑病(HE)的相关危险因素。 方法 行介入治疗的PLC患者93例，根据治疗效果分为好转组（32例）和恶化组（61例）。对两组患者年龄、性别、家族史、Child-Pugh分级、HE分期、肝癌分型、肝外转移、肝癌合并症以及腹腔淋巴结转移等22项PLC介入治疗后并发HE的相关因素进行统计学分析。 结果 肝癌合并症≥3个、肝癌合并肝硬化、凝血酶原时间、尿素氮、胆碱酯酶、Child-Pugh分级C级、HE分期Ⅲ～Ⅳ期为影响PLC介入治疗后并发HE的预后相关因素，Logistic多因素回归分析表明，肝癌合并症≥3个、Child-Pugh分级C级、HE分期Ⅲ～Ⅳ期为影响PLC介入治疗后并发HE预后的独立危险因素。 结论 肝癌合并症≥3个、Child-Pugh分级C级、HE分期Ⅲ～Ⅳ期可以作为评价PLC介入治疗后并发HE预后的标准。 [关键词] 肝肿瘤；肝性脑病；介入 Related risk factors analysis of hepatic encephalopathy after the prinmry liver cancer interventional treatment ZHANG Mu-gen. Department of Intervention，the 92nd Hospital of PLA, Fujian Nanping 353000 , China Email：nanpingzmg@163.com [Abstract] Objective To explore the related risk factors of hepatic encephalopathy (HE) after the primary liver cancer interventional treatment. Methods Ninety-three cases with primary liver cancer who were treated with interventional treatment were chosen. According to the result, all patients were divided into two groups,improving group (32 cases) and worsen group (61 cases). Collected the patients age,gender,family history, Child-Pugh classification, HE staging, liver cancer subtypes, extrahepatic transfer, liver cancer complications and lymph node metastases and other items,for all 22 items,and the results for statistical analysis. Results Complications more than 3 ,liver cancer combined with liver cirrhosis,prothrombin time,urea nitrogen, cholinesterase, Child-Pugh grading grade C, HE staging Ⅲ-Ⅳperiod were related factors for HE prognosis. Logistic regression analysis results showed that complications more than 3, Child-Pugh grading grade C,HE staging Ⅲ-Ⅳ period were independent risk factors for HE prognosis. Conclusions Complications more than 3, Child-Pugh grading grade C, HE staging Ⅲ- Ⅳ period were independent risk factors for HE prognosis. It can be used as evaluation standard for HE after the primary liver cancer interventional treatment. [ Key words ] Liver neoplasms；Hepatic encephalop