人的宫颈癌兔肌肉内移植瘤超声造影实验研究.pdfVIP

中国医学影像技术2008年第24卷第2期 Chin J Med Imaging Technol，2008，Vol 24，No 2 · 197 · ◆：．实验研究 The study of contrast-enhanced ultrasound in humans cervical cancer transplanted carcinoma of rabbit GAO Kui—rn，l ，SHI Tie-mei ，YANG Xiao—qing (1．Department of Ultrasound，Shengj ing Hospital of China Medical University，Shenyang 110003，China； 2．Department of Operation，Liaoning Provincial Tumor Hospital，Shenyang 1 10042，China) [Abstract] Objective To evaluate the diagnosis of tumors in rabbit muscles by using intravenous second harmonic imaging． Methods Ten rabbits with human cervical cancer transplanted tumors in muscle were examined．Sonovue was administered to ten rabbits through ear veins at 0．1，0．2，0．4 ml／kg，respectively，and then imaged with second harmonic imaging．After intravenous administration of contrast agent，color Doppler imaging or power Do ppler imaging were used to evaluate the blood perfusion within tumors．Results After injection，there were significant improvements in detecting neovascularity of tumor in muscle at all contrast agent dosage levels and the intensity lasted a long period．Conclusion The contrast agent is able to detect clearly the tumor vessels which cannot be shown with conventional color flow imaging．Moreover，the contrast agent can maintain the visuality of the vessels for a longer period．Time-strength curve can provide more valuable information in early diagnosing cervix tumor of rabbit． [Key words] Cervix neoplasms；Tumor cells；Contrast agent 人的宫颈癌兔肌肉内移植瘤超声造影实验研究 高岿然 ，史铁梅 ，杨晓清。 (1．中国医科大学盛京医院超声科，辽宁 沈阳 110003；2．辽宁省肿瘤医院手术室，辽宁 沈阳 110042) [摘 要] 目的 评价超声造影显像对人的官颈癌兔肌肉内移植瘤血流灌注检出作用。方法 经耳缘静脉建立静脉通道 后分别有0．1、0．2、0．4 ml／kg三种剂量观察水平，应用二次谐波显像观察肿瘤造影效果。同时观察兔肌肉层