五味子不同产地.pdfVIP

J. Sep. Sci. 2014, 37 , 731–737 731 Yinan Zhang1 Research Article Fen Li2 Fengjie Huang2 Guoxiang Xie3 Metabolomics analysis reveals variation in Runmin Wei2 Schisandra chinensis cetabolites from Tianlu Chen1 Jiajian Liu1 1 different origins Aihua Zhao Wei Jia1,3 Wu Wei Zi ( Schisandra chinensis), an important herbal medicine, is mainly distributed in the 1Center for Translational northeast of China. Its phytochemical compositions, which depend on geographical origin, Medicine, Shanghai Key climatic conditions and cultural practices, may vary largely among Wu Wei Zi from differ- Laboratory of Diabetes Mellitus, ent areas. In this study, we applied a comprehensive metabolite profiling approach using Department of Endocrinology and Metabolism, Shanghai Jiao GC–TOF-MS, ultra-performance LC (UPLC) quadrupole TOF (QTOF) MS and inductively Tong University Affiliated Sixth coupled plasma MS to systematically investigate the metabolite variations of S. chinensis People’s Hospital, Shanghai, P.R. from four different areas including Heilongjiang, Liaoning, Jilin, and Shanxi of China. China 2 A total of 65 primary metabolites, 35 secondary metabolites and 64 inorganic elements School of Pharmacy, Shanghai Jiao Tong University, Shanghai, were identified. Several primary metabolites, including shikimic acid and tricarboxylic acid China cycle intermediates, were abundant in those located in Heilongjiang, Jilin, and Liaoning. 3 University of Hawaii Cancer Besides, bioactive lignans are a