影像下臭氧治疗溃疡性结肠炎临床探究.docVIP

影像下臭氧治疗溃疡性结肠炎临床探究[摘要]目的探讨臭氧治疗溃疡性结肠炎的疗效。方法 对28例药物治疗效果差,无明显手术指针的溃疡性结肠炎患者,进行臭氧持续吹注治疗,并对患者进行疗效评估。疗效评估标准①患者腹痛、腹泻症状明显改善。②疗程结束后1月复查肠镜前后对照。结果 臭氧治疗1疗程后,腹痛缓解有效率82.1%,腹泻缓解有效率85.7%,结肠镜下观察病变肠粘膜明显好转,取得了良好的疗效。结论 臭氧的抗菌、消炎及免疫调节作用可能表现在对病变肠道环境的改变,从而影响细菌菌群及肠相关淋巴样组织,使肠道恢复正常平衡。 [关键词]臭氧; 溃疡性结肠炎 [中图分类号] R516.1[文献标识码]A [文章编号] 1005-0515(2010)-10-081-02 Image of ozone treatment of ulcerative colitis in clinical research [Abstract]ObjectiveTo investigate the efficacy of ozone treatment of ulcerative colitis. Methods28 patients with drug treatment is poor, non-surgical patients with ulcerative colitis pointers to carry out continuous blowing of ozone injection treatment, and patients assessed efficacy. Assessment criteria ① efficacy in patients with abdominal pain, diarrhea, symptoms improved significantly. ② review in January after the end of treatment before and after colonoscopy controls. ResultsOzone treatment of a course of treatment, abdominal pain, ease the efficiency was 82.1%, diarrhea 85.7% efficiency to ease, colon endoscopic mucosal lesions observed significant improvement achieved good effect. Conclusions The ozone anti-bacterial, anti-inflammatory and immune regulation may be reflected in changes in the environment of the intestinal disease, thereby affecting the bacterial flora and the gut-associated lymphoid tissue, so that normal balance of intestinal tract. [Keywords] Ozone; ulcerative colitis 溃疡性结肠炎是一种目前病因尚不十分清楚的直肠和结肠慢性非特异性炎症性疾病。临床上以腹痛、腹泻、黏液血便、发热、消瘦为主要表现,患者一般发病缓慢,病程漫长,病情轻重不一,常反复发作。〔1〕目前内科尚无特效药物治疗,外科手术指征严格,且疗效不确定。自2008年元月至今,我院疼痛科对28例药物治疗效果差,无明显手术指征的溃疡性结肠炎患者进行影像下臭氧持续吹注治疗,取得了良好的临床效果,现报道如下: 资料与方法: 1 一般资料2008年元月至今行臭氧治疗溃疡性结肠炎的患者,男15例,女13例,年龄最小21岁,最大50岁,,平均年龄35岁。病程最短3月,最长2年,平均病程10月。所有病例均为经两月以上正规药物治疗且效果不佳的患者。 2 方法及观测项目 2.1 检查:结肠镜检查:结合临床表现排除其他病因引起的肠道炎症改变。本研究中选取28例症状典型且结肠镜下有不同程度肠粘膜改变患者,均确诊为溃疡性结肠炎。 2.2 操作:做好肠道准备工作后,患者均取左侧卧位,从肛门插入润滑过的带导丝的一次性使用胃管(规格型号Ⅱ-18FR),至30cm时嘱患者取平卧,并压迫右下腹,继续插入导管,X线影像监视器证实导管头位于病灶部,拔出导丝,注入臭氧,速度控制在50-100ml/min,嘱患者轻揉腹部,注气完毕嘱患者平卧尽量不要排气,观察