cleansing formulations that respect skin barrier integrity清洗配方,尊重皮肤屏障的完整性.pdfVIP

Hindawi Publishing Corporation Dermatology Research and Practice Volume 2012, Article ID 495917, 9 pages doi:10.1155/2012/495917 Review Article Cleansing Formulations That Respect Skin Barrier Integrity Russel M. Walters,1 Guangru Mao,1 Euen T. Gunn,1 and Sidney Hornby2 1Johnson Johnson Consumer Products Companies, 199 Grandview Road, Skillman, NJ 08558, USA 2 Neutrogena Corporation, 5760 West 96th Street, RD Building, Los Angeles, CA 90045, USA Correspondence should be addressed to Russel M. Walters, rwalter2@ Received 25 April 2012; Accepted 25 June 2012 Academic Editor: Georgios Stamatas Copyright © 2012 Russel M. Walters et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Surfactants in skin cleansers interact with the skin in several manners. In addition to the desired benefit of providing skin hygiene, surfactants also extract skin components during cleansing and remain in the stratum corneum (SC) after rinsing. These side effects disrupt SC structure and degrade its barrier properties. Recent applications of vibrational spectroscopy and two- photon microscopy in skin research have provided molecular-level information to facilitate our understanding of the interaction between skin and surfactant. In the arena of commercial skin cleansers, technologies have been developed to produce cleansers that both cleanse and respect skin barrier. The main approach is to minimize surfactant interaction with skin through altering its solution properties. Recently, hydrophobically modified polymers (HMPs) have been introduced to create skin compatible cleansing systems. At t