LHRH类似物在卵巢癌治疗中的应用.doc

LHRH类似物在卵巢癌治疗中的应用 国外医学妇幼保健分册2003年第14卷第6期413 果;④所需剂量小;③对mdrl,LRP,Topo-1I的作用有同步 性.TNF在Esherichacoli中克隆成功使TNF有可能应用于 临床实验和治疗癌症.但其副作用:发热寒战,乏力不适,恶 心呕吐,胸痛等限制了其临床应用.目前以低剂量rHuT— NF联合化疗药是卵巢癌研究方向之一. [参考文献] 11【CoukosG.RubinSC.Chemotherapyresistencelnovariancan. cer:newmolecularperspectiveslJjObstetandGynecol,1998, 91(5):783789 [2]KigawaJ,MinagawaY,KanamoriY,etalGlutathionecon- centrationmaybeausefulpredictorofresponsetosecond—line chemotherapyinpatientswithovariancancer[J]Cancer, 1998.82(4):697702 [3]MaLorniW,RainaLdiG,TritareLLiE,etafTumornecrosis facteralphaisapowerfulopoptoticinducerinlymphoidleuke- miccellsexpressingtheP+17Oglycoprotein[J]IntJCancer, 1996.67(2):238247. I4lKomdeurR,PlaatBEC,HoekstraHJ,etnfExpressionof p-glycoprotein,multidrugresistance—associatedprotein1and lungresistance—relatedproteininhumansofttissuesarcomas beforeandafterhyperthermicisolatedlimbperfusionwithtu— mornecrosisfacter一口andmelphalan[J]Cancer,2001,91(10):[5]PrechtlS,RoellinghoffM,ScheperR,etalThemuhidrugre- sistenceprotein1:Afunctionallyimportantactivationmarker formurineth1cellsJJJImmunol,2000,164(2):754761 l6jLiburaJ,BettensF,RadkowskiA,etnf.Polymorphictumor necrosisfactermicrosatelliteTNF口4isassociatedwithresis- tanceofHodgkinlymphomatochemotherapyandwithrelapses aftertherapy[J].AnticancerRes,2002,22(2A):921—926 『71GalvaniV,PremarHK,RuprehtRR,etnf.Solubletumor necrosisfactorreceptorI(sTNFRI)asaprognosticfactorin melanomapatientsinSlovenepopulationlJjPflugersArch, 2000:440(5Supp1):R61—63 『8lMurdochWJ.Proteolyticandcellulardeathmechanismsin ovulatoryovarianrupturelJ』BiolSignalsRecept,2000,9(2): 1O2114 9jLiJ,KelseySM,GrahnMF,etnfIncreasedactivityand sensitivityofmitOchOndrialrespiratoryenzymestotumornecro. sisfacter0一mediatedinhibitionisassociatedwithincreasedcy. totoxicityindrug—resistantleukemiccelllines[J]Blood,1996, 87(6):2401241O I1OJSteinU,WaltherW,LaurencotCM,etnf.Tumornecrosis facter—alphaandexpressionofthemuLtidrugresistance—associat. edgenesLRPandMRP[J].JNatlCancerInst,1997,8