the bone niche of chondrosarcoma a sanctuary for drug resistance, tumour growth and also a source of new therapeutic targets骨软骨肉瘤的利基耐药性的避难所,肿瘤生长以及新的治疗靶点.pdfVIP

Hindawi Publishing Corporation Sarcoma Volume 2011, Article ID 932451, 8 pages doi:10.1155/2011/932451 Review Article The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets E. David,1, 2 F. Blanchard,1, 2 M. F. Heymann,1, 2, 3 G. De Pinieux,4, 5 F. Gouin,1, 2, 3 ´ 1, 2 1, 2, 3 F. Redini, and D. Heymann 1 INSERM, UMR 957, Physiopathologie de la R´esorption Osseuse et Th´erapie des Tumeurs Osseuses Primitives, Facult´e de M´edecine, 1 rue Gaston Veil, 44035 Nantes Cedex 1, 44035 Nantes, France 2 Universit´e de Nantes, Nantes Atlantique Universit´es, Laboratoire de Physiopathologie de la R´esorption Osseuse et Th´erapie des Tumeurs Osseuses Primitives, 44035 Nantes, France 3 University Hospital, Hˆotel Dieu, CHU de Nantes, 44035 Nantes, France 4 EA3855, University Hospital, 2 bd Tonnelle, 37044 Tours Cedex, France 5 University Hospital, Hˆopital Trousseau, CHRU de Tours, 37042 Tours Cedex, France Correspondence should be addressed to D. Heymann, dominique.heymann@univ-nantes.fr Received 25 November 2010; Revised 28 January 2011; Accepted 10 February 2011 Academic Editor: Ole Nielsen Copyright © 2011 E. David et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Chondrosarcomas are malignant cartilage-forming tumours representing around 20% of malignant primary tumours of bone and affect mainly adults in the third to sixth decade of life. Unfortunately, the molecular pathways controlling the genesis and the growth of chondrosarcoma cells are still not fully defined. It i