the myocyte expression of adiponectin receptors and pparδ is highly coordinated and reflects lipid metabolism of the human donors肌细胞脂联素受体的表达和pparδ高度协调,反映了人类捐助者的脂质代谢.pdfVIP

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the myocyte expression of adiponectin receptors and pparδ is highly coordinated and reflects lipid metabolism of the human donors肌细胞脂联素受体的表达和pparδ高度协调,反映了人类捐助者的脂质代谢.pdf

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the myocyte expression of adiponectin receptors and pparδ is highly coordinated and reflects lipid metabolism of the human donors肌细胞脂联素受体的表达和pparδ高度协调,反映了人类捐助者的脂质代谢

Hindawi Publishing Corporation Experimental Diabetes Research Volume 2011, Article ID 692536, 8 pages doi:10.1155/2011/692536 Research Article The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reﬂects Lipid Metabolism of the Human Donors Anna-Maria Ordelheide, Martin Heni, Nadja Gommer, Lisa Gasse, Carina Haas, ¨ Alke Guirguis, Fausto Machicao, Hans-Ulrich Haring, and Harald Staiger Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen and German Center for Diabetes Research (DZD e.V.), Tubingen, Germany ¨ ¨ ¨ Correspondence should be addressed to Hans-Ulrich Haring, hans-ulrich.haering@med.uni-tuebingen.de Received 3 September 2010; Revised 21 December 2010; Accepted 5 January 2011 Academic Editor: Toshiyasu Sasaoka Copyright © 2011 Anna-Maria Ordelheide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Muscle lipid oxidation is stimulated by peroxisome proliferator-activated receptor (PPAR) δ or adiponectin receptor signalling. We studied human myocyte expression of the PPARδ and adiponectin receptor genes and their relationship to lipid parameters of the donors. The mRNA levels of the three adiponectin receptors, AdipoR1, AdipoR2, and T-cadherin, were highly interrelated (r ≥ 0.91). However, they were not associated with GPBAR