the peroxisome proliferator-activated receptor gamma system regulates ultraviolet b-induced prostaglandin production in human epidermal keratinocytes的过氧物酶体proliferator-activated受体γ系统调节紫外线b-induced前列腺素生产人类表皮角化细胞.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2010, Article ID 467053, 8 pages doi:10.1155/2010/467053 Research Article The Peroxisome Proliferator-Activated Receptor Gamma System Regulates Ultraviolet B-Induced Prostaglandin E2 Production in Human Epidermal Keratinocytes Raymond L. Konger,1, 2 Kellie Clay Martel,1 Danielle Jernigan,1 Qiwei Zhang,2 and Jeffrey B. Travers2, 3, 4, 5 1 Department of Pathology Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA 2 Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA 3 Department of Pediatrics and the H. B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA 4 Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA 5 Department of Dermatology, Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA Correspondence should be addressed to Raymond L. Konger, rkonger@ Received 5 January 2010; Revised 2 March 2010; Accepted 11 March 2010 Academic Editor: Michael E. Robbins Copyright © 2010 Raymond L. Konger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Studies using PPARγ agonists in mouse skin have suggested that peroxisome proliferator-activated receptor gamma (PPARγ) is irrelevant to cutaneous photobiology. However, in several epithelial cell lines, ultraviolet B (UVB) has been shown to induce the nonenzymatic production of oxidized phospholipids that act as PPARγ agonists. UVB is also a potent inducer of prostaglandin E (PGE ) pro