贰型糖尿病患者中g6pd缺乏症的基因频率及其对糖化血红蛋白测定的影响（Gene frequency of G6PD deficiency and its impact on HbA1c in patients with type 2 diabetes mellitus）.doc

贰型糖尿病患者中g6pd缺乏症的基因频率及其对糖化血红蛋白测定的影响（Gene frequency of G6PD deficiency and its impact on HbA1c in patients with type 2 diabetes mellitus） Gene frequency of G6PD deficiency in type 2 diabetes mellitus and its effect on glycosylated hemoglobin measurement 2011-04-02 Li Wei Feng Taibao Xiao Zhenghua Chen Fan Han Jialian Table 1 Changes of G6PD/6PGD, Hb, HbA1c in erythrocytes of patients with type 2 diabetes mellitus (s) group The number of cases is G6PD/6PGD Hb (g/L) HbA1c (%) The normal control group was 362.03 + 0.17, 128.2 + 10.5, 6.51 + 1.49 Group G6PD+DM was 731.81 + 0.24*, 112 + 25.6**, 7.56 + 2.83* G6PD group DM 50.66 + 0.37** 115.9 + 17.1* 6 + 3.71 Note: compared with the control group, *P 0.05, **P 0.01, hereditary glucose -6- phosphate dehydrogenase (G6PD) deficiency is a kind of X- linked incomplete dominant hereditary disease, which has regional and national differences in china. Foreign G6PD patients reported diabetes deficiency prevalence rate is higher than the normal population, Diabet, Med, 1985,2:110, Guangdong is Chinas high incidence of G6PD deficiency, we preliminary investigation of the Guangdong nationality G6PD patients with type 2 diabetes in lack of gene frequency of disease, and to explore the clinical significance of G6PD deficiency in diabetes. First, objects and methods 1. subjects: 78 patients with type 2 diabetes diagnosed according to the WHO diagnostic criteria in 1985 (38 males and 40 females), with an average age of 62 years (40~85 years), and 36 healthy subjects of similar age group as the control group. Both Guangdong nationality and Han nationality. 2. methods: (1) determination of erythrocyte G6PD activity: kit was provided by the Department of genetics, Zhongshan medical university. Hemoglobin (Hb) concentration was measured by cyanide methemoglobin. The ratio of G6PD/6PGD to 1 is the basis of G6PD deficiency. (2) biochemical indexes: glycosylated hemoglobin (HbA1c) was determined by ion exchange column chromatography on automat