analysis of the somatostatin type ii receptor expressed in pancreatic cancer adjacent tissues（生长激素抑制素ii型受体表达的分析胰腺癌邻近组织）.doc

Analysis of the somatostatin type II receptor expressed in pancreatic cancer adjacent tissues : Fang Ruliang Liuzhi Mei Yan Tingjun cover school silver Wang Xin Qin Renyi [Keywords:] somatostatin [Abstract] Objective To understand the organization of the primary pancreatic cancer and adjacent tissue somatostatin receptor type Ⅱ (SST2R of expression, to explore the reasons for the inconsistency of the effect of somatostatin and its analogues treatment of pancreatic tumor. Using immunohistochemistry LSAB method detected 40 cases of primary pancreatic cancer tissues and adjacent tissues of 3 cm SST2R expression differences the SST2R expression in primary pancreatic cancer tissues and adjacent tissues, and analyzed with the χ2 test. results of pancreatic cancer tissues and cancer adjacent tissues at the same time express SST2R five cases, positive expression rate was 12.5% #8203;#8203;(5/40, the organization SST2R next to the pancreatic cancer positive expression rate of 85% (34/40), 29 cases of pancreatic cancer next only tissue, pancreatic cancer the organization SST2R next The positive expression rate was significantly higher than that of pancreatic cancer tissues (P lt;0.05. the conclusion SST2R expression in different pancreatic cancer patients and in the same patients with pancreatic cancer tissues and adjacent tissues in significant differences, which may be of somatostatin and its analogue treatment of pancreatic cancer effect inconsistent important reason. [Keywords:] pancreatic cancer adjacent tissues, somatostatin II receptor, immunohistochemistry [Abstract] ObjectiveThe current study was designed to investigate somatostatin receptor subtype 2 gene expression in tumor tissues and non-carcinoma adjacent tissues of primary pancreatic carcinoma, and explore the cause of the difference in the treatment against pancreatic neoplasms by exogenous somatostatin and its analogues. MethodsThe expression of SST2R in tumor tissues and non-carcinoma adjace