huntingtons disease the case for genetic modifiers亨廷顿氏舞蹈症基因修饰符.pdfVIP

Review Huntington’s disease: the case for genetic modifiers James F Gusella and Marcy E MacDonald Address: Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA. Correspondence: James F Gusella. E-mail: gusella@ loss of neurons, most notably in the striatum and, less Abstract distinctly, in the cerebral cortex. The age at which HD can For almost