a putative homologue of cdc20cdh1 in the malaria parasite is essential for male gamete development假定的同系物的cdc20cdh1疟原虫雄性配子发展至关重要.pdfVIP

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2017-09-07 发布于上海
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a putative homologue of cdc20cdh1 in the malaria parasite is essential for male gamete development假定的同系物的cdc20cdh1疟原虫雄性配子发展至关重要.pdf

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a putative homologue of cdc20cdh1 in the malaria parasite is essential for male gamete development假定的同系物的cdc20cdh1疟原虫雄性配子发展至关重要

A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development 1 2 1 1 3 4 David S. Guttery , David J. P. Ferguson , Benoit Poulin , Zhengyao Xu , Ursula Straschil , Onny Klop , 5 1 1 1 4 Lev Solyakov , Sara M. Sandrini , Declan Brady , Conrad A. Nieduszynski , Chris J. Janse , Anthony A. 6 5 1,3 Holder , Andrew B. Tobin , Rita Tewari * 1 Centre for Genetics and Genomics, School of Biology Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom, 2 Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, 3 Division of Cell and Molecular Biology, Imperial College London, London, United Kingdom, 4 Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical, Leiden, The Netherlands, 5 Department of Cell Physiology and Pharmacology, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, 6 Division of Parasitology, MRC National Institute for Medical Research, London, United Kingdom Abstract Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/ cyclosome (APC/C) in mitosis, and facilitate degradation of mitotic APC/C substrates. The malaria parasite, Plasmodium, is a haploid organism which, during its life-cycle undergoes two stages of mitosis; one asso