a systematic survey and characterization of enhancers that regulate sox3 in neuro-sensory development in comparison with sox2 enhancers系统的调查和描述的增强剂调节sox3 neuro-sensory发展相比,sox2增强剂.pdfVIP

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a systematic survey and characterization of enhancers that regulate sox3 in neuro-sensory development in comparison with sox2 enhancers系统的调查和描述的增强剂调节sox3 neuro-sensory发展相比,sox2增强剂.pdf

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a systematic survey and characterization of enhancers that regulate sox3 in neuro-sensory development in comparison with sox2 enhancers系统的调查和描述的增强剂调节sox3 neuro-sensory发展相比,sox2增强剂

Biology 2012, 1, 714-735; doi:10.3390/biology1030714 OPEN ACCESS biology ISSN 2079-7737 /journal/biology Article A Systematic Survey and Characterization of Enhancers that Regulate Sox3 in Neuro-Sensory Development in Comparison with Sox2 Enhancers Naoko Nishimura, Yoshifumi Kamimura, Yoshiko Ishida, Tatsuya Takemoto, Hisato Kondoh * and Masanori Uchikawa * Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan; E-Mails: monster1116s@yahoo.co.jp (Y.K.); ishida-yoshiko@ (Y.I.); take@fbs.osaka-u.ac.jp (T.T.) * Authors to whom correspondence should be addressed; E-Mails: kondohh@fbs.osaka-u.ac.jp (H.K.); uchikawa@fbs.osaka-u.ac.jp (M.U.); Tel: 81-6-6879-7963; Fax: 81-6-6877-1738; Tel: 81-6-6879-7964; Fax: 81-6-6877-1738. Received: 17 October 2012; in revised form: 6 November 2012 / Accepted: 9 November 2012 / Published: 22 November 2012 Abstract: Development of neural and sensory primordia at the early stages of embryogenesis depends on the activity of two B1 Sox transcription factors, Sox2 and Sox3. The embryonic expression patterns of the Sox2 and Sox3 genes are similar, yet they show gene-unique features. We screened for enhancers of the 231-kb genomic region encompassing Sox3 of chicken, and identified 13 new enhancers that showed activity in different domains of the neuro-sensory primordia. Combined with the three Sox3-proximal enhancers determined previously, at least 16 enhancers were involved in Sox3 regulati