accumulation of secretory vesicles in the lacrimal gland epithelia is related to non-sj？grens type dry eye in visual display terminal users积累的泪腺分泌囊泡上皮细胞与non-sj gren类型干眼的视觉显示终端用户.pdfVIP

Accumulation of Secretory Vesicles in the Lacrimal Gland ¨ Epithelia Is Related to Non-Sjogren’s Type Dry Eye in Visual Display Terminal Users 1 1 1 1 2 3 Mizuka Kamoi , Yoko Ogawa *, Shigeru Nakamura , Murat Dogru , Toshihiro Nagai , Hiroto Obata , 4 1 1 2 5 Masataka Ito , Minako Kaido , Tetsuya Kawakita , Yasunori Okada , Yutaka Kawakami , Shigeto Shimmura1, Kazuo Tsubota1 1 Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan, 2 Department of Pathology, Keio University School of Medicine, Tokyo, Japan, 3 Department of Ophthalmology, Jichi Medical University, Tochigi, Japan, 4 Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Saitama, Japan, 5 Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan Abstract ¨ Previous observations in a rat model of a non-Sjogren’s syndrome (non-SS) type of dry eye seen in users of visual display terminals (VDT) indicated that secretory vesicle (SV) accumulation in the lacrimal gland epithelia contributes to the condition. Here, to examine this possibility in humans, we compared the lacrimal gland histology and percent SV area in the cytoplasm of acinar epithelial cells using light microscopy and transmission electron microscopy, in patients with VDT work- related non-SS dry-eye (VDT group), SS-induced dry-eye, and autopsied normal controls. In addition, the VAMP8