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accurate and rapid estimation of phosphene thresholds (rept)准确和快速的估计光幻视阈值(报告).pdf

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accurate and rapid estimation of phosphene thresholds (rept)准确和快速的估计光幻视阈值(报告)

Accurate and Rapid Estimation of Phosphene Thresholds (REPT) 1 1 2 3 4 Arman Abrahamyan *, Colin W. G. Clifford , Manuela Ruzzoli , Dan Phillips , Ehsan Arabzadeh , Justin A. Harris1 1 School of Psychology, The University of Sydney, Sydney, New South Wales, Australia, 2 Cognitive Neuroscience Section, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy, 3 The Magstim Company Ltd, Whitland, Wales, United Kingdom, 4 School of Psychology, The University of New South Wales, Sydney, New South Wales, Australia Abstract To calibrate the intensity of transcranial magnetic stimulation (TMS) at the occipital pole, the phosphene threshold is used as a measure of cortical excitability. The phosphene threshold (PT) refers to the intensity of magnetic stimulation that induces illusory flashes of light (phosphenes) on a proportion of trials. The existing PT estimation procedures lack the accuracy and mathematical rigour of modern threshold estimation methods. We present an improved and automatic procedure for estimating the PT which is based on the well-established Y Bayesian adaptive staircase approach. To validate the new procedure, we compared it with another commonly used procedure for estimating the PT. We found that our procedure is more accurate, reliable, and rapid when compared with an existing PT measurement procedure. The new procedure is implemented in Matlab and works automatically with the Magstim Rapid2 stimulator using a convenient graphical user interface. The Matlab program is freely available for download. Citation: Abrahamyan A, Clifford CWG, Ruzzoli M, Phillips D, Arabzadeh E, et al. (2011) Accurate and Rapid Est