原创力文档amelioration of experimental autoimmune encephalomyelitis in c57bl6 mice by photobiomodulation induced by 670 nm light在c57bl6小鼠实验性自身免疫性脑脊髓炎的改良photobiomodulation引起670海里.pdfVIP
- 1、本文档共9页，可阅读全部内容。
- 2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
- 3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
amelioration of experimental autoimmune encephalomyelitis in c57bl6 mice by photobiomodulation induced by 670 nm light在c57bl6小鼠实验性自身免疫性脑脊髓炎的改良photobiomodulation引起670海里
Amelioration of Experimental Autoimmune
Encephalomyelitis in C57BL/6 Mice by
Photobiomodulation Induced by 670 nm Light
¤
Kamaldeen A. Muili , Sandeep Gopalakrishnan, Stacy L. Meyer, Janis T. Eells, Jeri-Anne Lyons*
Department of Health Sciences, College of Health Sciences, University of Wisconsin–Milwaukee, Milwaukee, Wisconsin, United States of America
Abstract
Background: The approved immunomodulatory agents for the treatment of multiple sclerosis (MS) are only partially
effective. It is thought that the combination of immunomodulatory and neuroprotective strategies is necessary to prevent
or reverse disease progression. Irradiation with far red/near infrared light, termed photobiomodulation, is a therapeutic
approach for inflammatory and neurodegenerative diseases. Data suggests that near-infrared light functions through
neuroprotective and anti-inflammatory mechanisms. We sought to investigate the clinical effect of photobiomodulation in
the Experimental Autoimmune Encephalomyelitis (EAE) model of multiple sclerosis.
Methodology/Principal Findings: The clinical effect of photobiomodulation induced by 670 nm light was investigated in
the C57BL/6 mouse model of EAE. Disease was induced with myelin oligodendrocyte glycoprotein (MOG) according to
standard laboratory protocol. Mice received 670 nm light or no light treatment (sham) administered as suppression and
treatment protocols. 670 nm light reduced disease severity with both protocols compared to sham treated mice. Disease
amelioration was associated with down-regulation of proinflammatory cytokines (interferon-c, tumor necrosis factor-a) and
up-regulation of anti-inflammatory cytokines (IL-4, IL-10) in vitro and in vivo.
Conclusion/Significance: These studies document the therapeutic potential of photobiomodulation with 670 nm light i
您可能关注的文档
- aerosolized bc-819 inhibits primary but not secondary lung cancer growth雾化bc - 819抑制肺癌主要但不是次要的增长.pdf
- affiliative behavior, ultrasonic communication and social reward are influenced by genetic variation in adolescent mice亲和行为,超声波交流和社会奖励在青春期小鼠遗传变异的影响.pdf
- afm-detected apoptotic changes in morphology and biophysical property caused by paclitaxel in ishikawa and hela cellsafm-detected凋亡形态学和生物物理属性的变化引起的紫杉醇在石川和海拉细胞.pdf
- aflatoxin-induced tp53 r249s mutation in hepatocellular carcinoma in thailand association with tumors developing in the absence of liver cirrhosisaflatoxin-induced tp53 r249s突变肝细胞癌在泰国与肿瘤发展没有肝硬化.pdf
- african ancestry and its correlation to type 2 diabetes in african americans a genetic admixture analysis in three u.s. population cohorts非洲血统2型糖尿病及其相关的非裔美国人的基因混合分析三个美国人口群体.pdf
- after-school based obesity prevention interventions a comprehensive review of the literature课后根据肥胖预防干预措施的全面审查文学.pdf
- aflatoxin regulations in a network of global maize trade全球玉米贸易网络中的黄曲霉毒素规定.pdf
- agarase review of major sources, categories, purification method, enzyme characteristics and applicationsagarase审查的主要来源,分类,净化方法,酶的特点和应用.pdf
- agdscam, a hypervariable immunoglobulin domain-containing receptor of the anopheles gambiae innate immune systemagdscam,变异度高的免疫球蛋白domain-containing受体冈比亚疟蚊的先天免疫系统.pdf
- african ancestry is associated with asthma risk in african americans非洲血统与哮喘有关的风险的非裔美国人.pdf
- amino-acid co-variation in hiv-1 gag subtype c hla-mediated selection pressure and compensatory dynamics在hiv - 1氨基酸共变gag c亚型hla-mediated选择压力和动态补偿.pdf
- amino acids transitioning of 2009 h1n1pdm in taiwan from 2009 to 2011氨基酸转变2009 h1n1pdm台湾从2009年到2011年.pdf
- ammonia oxidizing bacteria community dynamics in a pilot-scale wastewater treatment plant氨氧化细菌群落动态半工业规模的污水处理厂.pdf
- ammonificins c and d, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, thermovibrio ammonificansammonificins c和d,hydroxyethylamine chromene衍生品从细菌培养海洋深海热液喷口,thermovibrio ammonificans.pdf
- ammonia uptake and release in the mnx2–nh3 (x = cl, br) systems and structure of the mn(nh3)nx2 (n = 6, 2) ammines氨的吸收和释放mnx2-nh3(x = cl,br)系统和结构的锰(nh3)nx2(n = 6,2)氨合物.pdf
- ammonium toxicity and potassium limitation in yeast在酵母毒性和钾铵限制.pdf
- amitriptyline-mediated cognitive enhancement in aged 3×tg alzheimer's disease mice is associated with neurogenesis and neurotrophic activityamitriptyline-mediated认知增强3×岁tg阿尔茨海默病小鼠神经发生和神经营养活性相关联.pdf
- aminoacyl-trna-charged eukaryotic elongation factor 1a is the bona fide substrate for legionella pneumophila effector glucosyltransferasesaminoacyl-trna-charged真核延长因子1是嗜肺性军团菌的善意基质效应葡糖基转移酶.pdf
- aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cellsaminopropyltransferases参与聚胺生物合成在植物细胞的细胞核定位优先.pdf
- amniotic epithelial cells from the human placenta potently suppress a mouse model of multiple sclerosis羊膜上皮细胞从人类胎盘强有力地抑制小鼠模型的多发性硬化症.pdf
文档评论（0）