structural olfactory nerve changes in patients suffering from idiopathic intracranial hypertension结构性嗅觉神经病人患有特发性颅内高压的变化.pdfVIP

Structural Olfactory Nerve Changes in Patients Suffering from Idiopathic Intracranial Hypertension 1. 1. 2 1 2 Christoph Schmidt , Edzard Wiener , Jan Hoffmann , Randolf Klingebiel , Felix Schmidt , 3 2 2 Tobias Hofmann , Lutz Harms , Hagen Kunte * ´ ¨ ´ ¨ 1 Institute of Radiology, Charite-Universitatsmedizin Berlin, Berlin, Germany, 2 Department of Neurology, Charite-Universitatsmedizin Berlin, Berlin, Germany, ´ ¨ 3 Department of Psychosomatic Medicine, Charite-Universitatsmedizin Berlin, Berlin, Germany Abstract Background: Complications of idiopathic intracranial hypertension (IIH) are usually caused by elevated intracranial pressure (ICP). In a similar way as in the optic nerve, elevated ICP could also compromise the olfactory nerve system. On the other side, there is growing evidence that an extensive lymphatic network system around the olfactory nerves could be disturbed in cerebrospinal fluid disorders like IIH. The hypothesis that patients with IIH suffer from hyposmia has been suggested in the past. However, this has not been proven in clinical studies yet. This pilot study investigates whether structural changes of the olfactory nerve system can be detected in patients with IIH. Methodology/Principal Findings: Twenty-three patients with IIH and 23 matched controls were included. Olfactory bulb volume (OBV) and sulcus olfactorius (OS) depth were calculated by magnetic resonance techniques. While mean values of total OBV (128.7 638.4 vs. 130.0632.6 mm3, p = 0.90) and mea