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discovery of proteomic code with mrna assisted protein folding发现的蛋白质组学代码与mrna辅助蛋白质折叠
Int. J. Mol. Sci. 2008, 9, 2424-2446; DOI: 10.3390/ijms9122424
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms/
Review
Discovery of Proteomic Code with mRNA Assisted Protein
Folding
Jan C. Biro
Homulus Foundation, 612 S Flower St, Los Angeles, 90 017 CA, USA. E-Mail: jan.biro@;
Tel. +1-213-627-6134
Received: 18 August 2008; in revised form: 24 November 2008 / Accepted: 2 December 2008 /
Published: 3 December 2008
Abstract: The 3x redundancy of the Genetic Code is usually explained as a necessity to
increase the mutation-resistance of the genetic information. However recent
bioinformatical observations indicate that the redundant Genetic Code contains more
biological information than previously known and which is additional to the 64/20
definition of amino acids. It might define the physico-chemical and structural properties
of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the
coded proteins and the free folding energy of mRNAs. This additional information, which
seems to be necessary to determine the 3D structure of coding nucleic acids as well as the
coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding.
Keywords: Gene, code, codon, translation, wobble-base.
1. Introduction
Mapping between messages in nucleic acid and protein alphabet is a fascinating story, a story that
still unf
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