尼莫地平对高血压脑出血血肿吸收及神经功能影响.docVIP

尼莫地平对高血压脑出血血肿吸收及神经功能影响 　【摘要】 目的：探讨尼莫地平对高血压脑出血血肿吸收及神经功能恢复的影响. 方法：选择发病24 h内入院的高血压脑出血患者42例，随机分为治疗组（n=22）和对照组（n=20）. 两组均给于常规治疗，治疗组应用尼莫地平注射液10 mg/d，连续用10 d后，改为口服或胃管注入40 mg/次，3次/d，共用1 mo. 分别比较两组患者治疗后的血肿量、水肿面积及中国卒中评分(CSS)，并比较两组的临床疗效. 结果：治疗2 wk后治疗组血肿量和水肿面积均较对照组显著减少 (Plt;0.05)；治疗组临床显效率50.0%，总有效率86.4%，明显高于对照组的的20.0%和55.0%(Plt;0.05)；治疗2 wk后治疗组CSS明显低于对照组（Plt;0.05），治疗1 mo和3 mo后两组的差异更加显著（Plt;0.01）. 结论：尼莫地平早期应用于高血压脑出血的治疗有利于血肿的吸收及脑水肿的减轻，能够改善脑出血患者预后. 【关键词】 尼莫地平；脑出血；高血压 　　【Abstract】 AIM: To explore the effects of Nimodipine on hematoma absorption and neurofunction recovery in hypertensive cerebral hemorrhage. METHODS: Fortytwo patients with hypertensive cerebral hemorrhage hospitalized in 24 h were divided into study group (n=22) and control group (n=20) randomly. Based on conventional therapy, study group were treated with Nimodipine parenteral solution (10 mg/d). After 10 d, Nimodipine was given by peros or gastric tubes at the dosage of 40 mg each time (thrice per day), and it lasted for 1 month. And the hematoma quantity, encephaledema areas and CSS scores were compared between the 2 groups after treatment. And the clinic therapeutic effects were also compared. RESULTS: After 2week treatment, the hematoma quantity and the hydroncus areas of the study group were significantly decreased compared with those of the control group (Plt;0.05). The clinic effective rate (50.0%) and the overall effective rate (86.4%) were significantly higher than those of the control group with 20.0% and 55.0% respectively (Plt;0.05). The CSS scores of the study group were significantly lower than those of the control group after 2week treatment (Plt;0.05), and the differences were more significant at 1 month and 3 months after treatment (Plt;0.01). CONCLUSION: Early using Nimodipine for hypertensive cerebral hemorrhage has good effects on hematoma absorption, encephaledema relief and prognosis improvement. 　　【Keywords】 Nimodipine; cerebral hemorrhage; hypertension 　　0引言 　　高血压脑出血造成脑损害的最重要因素是血肿本身占位效